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Spn85F Serpin 85F [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41221, updated on 2-Nov-2024

Summary

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Official Symbol
Spn85Fprovided by FlyBase
Official Full Name
Serpin 85Fprovided by FlyBase
Primary source
FLYBASE:FBgn0037772
Locus tag
Dmel_CG12807
See related
AllianceGenome:FB:FBgn0037772
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12807; Dmel\CG12807
Summary
Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Orthologous to human AGT (angiotensinogen); HMSD (histocompatibility minor serpin domain containing); and SERPINH1 (serpin family H member 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Spn85F in Genome Data Viewer
Location:
85F5-85F5; 3-49 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9997163..10000314)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5822885..5826036)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Glucose transporter 4 enhancer factor Neighboring gene mir-9371 stem loop Neighboring gene Gustatory receptor 85a Neighboring gene uncharacterized protein Neighboring gene Molecule interacting with CasL Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila MICAL regulates myofilament organization and synaptic structure. Beuchle D, et al. Mech Dev, 2007 May. PMID 17350233
  2. The Drosophila serpins: multiple functions in immunity and morphogenesis. Reichhart JM, et al. Methods Enzymol, 2011. PMID 21683256
  3. Identification and analysis of serpin-family genes by homology and synteny across the 12 sequenced Drosophilid genomes. Garrett M, et al. BMC Genomics, 2009 Oct 22. PMID 19849829, Free PMC Article
  4. Identification of miR-305, a microRNA that promotes aging, and its target mRNAs in Drosophila. Ueda M, et al. Genes Cells, 2018 Feb. PMID 29314553
  5. Adult and Larval Tracheal Systems Exhibit Different Molecular Architectures in Drosophila. Bossen J, et al. Int J Mol Sci, 2023 Mar 15. PMID 36982710, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables peptidase inhibitor activity IKR
Inferred from Key Residues
more info
 PubMed 
NOT enables serine-type endopeptidase inhibitor activity IKR
Inferred from Key Residues
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
serpin 85F
Names
CG12807-PA
Spn85F-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    9997163..10000314
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141708.3 → NP_649965.2  serpin 85F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649965.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VH46
    Conserved Domains (1) summary
    cl00137
    Location:450 → 634
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VH46 Q9VH46

Gene LinkOut

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