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Spn85F Serpin 85F [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41221, updated on 29-Dec-2023

Summary

Official Symbol
Spn85Fprovided by FlyBase
Official Full Name
Serpin 85Fprovided by FlyBase
Primary source
FLYBASE:FBgn0037772
Locus tag
Dmel_CG12807
See related
AllianceGenome:FB:FBgn0037772
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12807; Dmel\CG12807
Summary
Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; angioedema (multiple); cerebral infarction; pancreatitis; and toxic shock syndrome. Orthologous to human SERPING1 (serpin family G member 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See Spn85F in Genome Data Viewer
Location:
85F5-85F5; 3-49 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9997163..10000314)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5822885..5826036)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Glucose transporter 4 enhancer factor Neighboring gene mir-9371 stem loop Neighboring gene Gustatory receptor 85a Neighboring gene uncharacterized protein Neighboring gene Molecule interacting with CasL Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

General protein information

Preferred Names
serpin 85F
Names
CG12807-PA
Spn85F-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    9997163..10000314
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141708.3NP_649965.2  serpin 85F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649965.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VH46
    Related
    FBpp0081649, FBtr0082171
    Conserved Domains (1) summary
    cl00137
    Location:450634
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...