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MAGEB4 MAGE family member B4 [ Homo sapiens (human) ]

Gene ID: 4115, updated on 5-Mar-2024

Summary

Official Symbol
MAGEB4provided by HGNC
Official Full Name
MAGE family member B4provided by HGNC
Primary source
HGNC:HGNC:6811
See related
Ensembl:ENSG00000120289 MIM:300153; AllianceGenome:HGNC:6811
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT3.6
Summary
This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEB genes are clustered on chromosome Xp22-p21. This gene sequence ends in the first intron of MAGEB1, another family member. This gene is expressed in testis. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

Location:
Xp21.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (30242000..30244187)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (29834351..29836538)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (30260117..30262304)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chrX:30232864-30234063 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:30236871-30237370 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:30237442-30238027 Neighboring gene MAGE family member B2 Neighboring gene NANOG hESC enhancer GRCh37_chrX:30246492-30247101 Neighboring gene MAGE family member B3 Neighboring gene NANOG hESC enhancer GRCh37_chrX:30259792-30260365 Neighboring gene MAGE family member B1 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:30274564-30274739 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:30300409-30300510 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chrX:30301194-30302393 Neighboring gene CRISPRi-validated cis-regulatory element chrX.505 Neighboring gene phospholipase C epsilon 1 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:30326716-30327216 Neighboring gene NR0B1 5' regulatory region Neighboring gene nuclear receptor subfamily 0 group B member 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC33144

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
melanoma-associated antigen B4
Names
MAGE-B4 antigen
cancer/testis antigen family 3, member 6
melanoma antigen family B, 4
melanoma antigen family B4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_015870.1 RefSeqGene

    Range
    5061..7248
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002367.4NP_002358.1  melanoma-associated antigen B4

    Status: REVIEWED

    Source sequence(s)
    AK313769, BC032852
    Consensus CDS
    CCDS14221.1
    UniProtKB/Swiss-Prot
    B2R9G0, O15481, Q6FHH4, Q8IZ00
    Related
    ENSP00000368266.2, ENST00000378982.4
    Conserved Domains (2) summary
    pfam01454
    Location:129283
    MAGE; MAGE family
    pfam12440
    Location:591
    MAGE_N; Melanoma associated antigen family N terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    30242000..30244187
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    29834351..29836538
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)