Format

Send to:

Choose Destination

MAGEB3 MAGE family member B3 [ Homo sapiens (human) ]

Gene ID: 4114, updated on 11-Jun-2021

Summary

Official Symbol
MAGEB3provided by HGNC
Official Full Name
MAGE family member B3provided by HGNC
Primary source
HGNC:HGNC:6810
See related
Ensembl:ENSG00000198798 MIM:300152
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT3.5
Summary
This gene is a MAGE-B subfamily member of the MAGE gene family. MAGE family member proteins direct the expression of tumor antigens recognized on a human melanoma by autologous cytolytic T lymphocytes. There are two known clusters of MAGE genes on chromosome X. The members of the MAGE-A subfamily are located in the Xq28 region, while the members of the MAGE-B subfamily are clustered in the Xp21 region. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 3.0) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See MAGEB3 in Genome Data Viewer
Location:
Xp21.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (30230657..30237495)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (30248774..30255612)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985632 Neighboring gene MAGE family member B2 Neighboring gene MAGE family member B4 Neighboring gene MAGE family member B1 Neighboring gene CRISPRi-validated cis-regulatory element chrX.504

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
melanoma-associated antigen B3
Names
MAGE-B3 antigen
cancer/testis antigen family 3, member 5
melanoma antigen family B, 3
melanoma antigen family B3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_015869.1 RefSeqGene

    Range
    5001..12058
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001386865.1NP_001373794.1  melanoma-associated antigen B3

    Status: REVIEWED

    Source sequence(s)
    AC005185
    Related
    ENSP00000478513.1, ENST00000620842.1
    Conserved Domains (2) summary
    pfam01454
    Location:129286
    MAGE; MAGE family
    pfam12440
    Location:593
    MAGE_N; Melanoma associated antigen family N terminal
  2. NM_002365.5NP_002356.2  melanoma-associated antigen B3

    See identical proteins and their annotated locations for NP_002356.2

    Status: REVIEWED

    Source sequence(s)
    AC005185
    Consensus CDS
    CCDS14220.1
    UniProtKB/Swiss-Prot
    O15480
    Related
    ENSP00000355198.2, ENST00000361644.4
    Conserved Domains (2) summary
    pfam01454
    Location:129286
    MAGE; MAGE family
    pfam12440
    Location:593
    MAGE_N; Melanoma associated antigen family N terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    30230657..30237495
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545513.2XP_011543815.1  melanoma-associated antigen B3 isoform X1

    See identical proteins and their annotated locations for XP_011543815.1

    UniProtKB/Swiss-Prot
    O15480
    Conserved Domains (2) summary
    pfam01454
    Location:129286
    MAGE; MAGE family
    pfam12440
    Location:593
    MAGE_N; Melanoma associated antigen family N terminal
Support Center