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MAGEA12 MAGE family member A12 [ Homo sapiens (human) ]

Gene ID: 4111, updated on 12-Aug-2018

Summary

Official Symbol
MAGEA12provided by HGNC
Official Full Name
MAGE family member A12provided by HGNC
Primary source
HGNC:HGNC:6799
See related
Ensembl:ENSG00000213401 MIM:300177; Vega:OTTHUMG00000022650
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT1.12; MAGE12
Summary
This gene is closely related to several other genes clustered on chromosome X. These genes may be overexpressed in tumors. Multiple alternatively spliced variants encoding the same protein have been identified. [provided by RefSeq, Jun 2014]
Expression
Restricted expression toward testis (RPKM 1.8) See more
Orthologs

Genomic context

See MAGEA12 in Genome Data Viewer
Location:
Xq28
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (152733779..152737669)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (151899293..151903184, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MAGE family member A2B Neighboring gene chondrosarcoma associated gene 1 Neighboring gene CSAG family member 4 (pseudogene) Neighboring gene MAGE family member A2 Neighboring gene CSAG family member 3 Neighboring gene MAGE family member A6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
melanoma-associated antigen 12
Names
MAGE12F antigen
cancer/testis antigen 1.12
cancer/testis antigen family 1, member 12
melanoma antigen family A, 12
melanoma antigen family A12

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_015852.2 RefSeqGene

    Range
    4962..8852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001166386.3NP_001159858.1  melanoma-associated antigen 12

    See identical proteins and their annotated locations for NP_001159858.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 all encode the same protein.
    Source sequence(s)
    AC244102
    Consensus CDS
    CCDS76048.1
    UniProtKB/Swiss-Prot
    P43365
    Related
    ENSP00000377478.3, ENST00000393900.4
    Conserved Domains (2) summary
    pfam01454
    Location:116280
    MAGE; MAGE family
    pfam12440
    Location:594
    MAGE_N; Melanoma associated antigen family N terminal
  2. NM_001166387.3NP_001159859.1  melanoma-associated antigen 12

    See identical proteins and their annotated locations for NP_001159859.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 all encode the same protein.
    Source sequence(s)
    AC244102
    Consensus CDS
    CCDS76048.1
    UniProtKB/Swiss-Prot
    P43365
    Related
    ENSP00000377447.3, ENST00000393869.7
    Conserved Domains (2) summary
    pfam01454
    Location:116280
    MAGE; MAGE family
    pfam12440
    Location:594
    MAGE_N; Melanoma associated antigen family N terminal
  3. NM_005367.6NP_005358.2  melanoma-associated antigen 12

    See identical proteins and their annotated locations for NP_005358.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 all encode the same protein.
    Source sequence(s)
    AC244102
    Consensus CDS
    CCDS76048.1
    UniProtKB/Swiss-Prot
    P43365
    Related
    ENSP00000350592.4, OTTHUMP00000024231, ENST00000357916.8, OTTHUMT00000058764
    Conserved Domains (2) summary
    pfam01454
    Location:116280
    MAGE; MAGE family
    pfam12440
    Location:594
    MAGE_N; Melanoma associated antigen family N terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    152733779..152737669
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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