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CG11975 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41074, updated on 18-Sep-2024

Summary

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Official Symbol
CG11975provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0037648
Locus tag
Dmel_CG11975
See related
AllianceGenome:FB:FBgn0037648
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG11975
Summary
Predicted to enable phosphatidylinositol-3,5-bisphosphate binding activity and phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in several processes, including autophagy of mitochondrion; autophagy of nucleus; and protein localization to phagophore assembly site. Predicted to be active in cytosol and phagophore assembly site membrane. Predicted to be extrinsic component of membrane. Orthologous to human WDR45B (WD repeat domain 45B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
85C1-85C1; 3-48 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8993253..8995212)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4818975..4820934)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Carbonic anhydrase beta Neighboring gene Ras-related GTP binding A/B Neighboring gene uncharacterized protein Neighboring gene Enhancer of variegation 3-9 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Proteasome beta3 subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phosphatidylinositol 3,5-bisphosphate: metabolism and cellular functions. Michell RH, et al. Trends Biochem Sci, 2006 Jan. PMID 16364647
  2. Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors. Dove SK, et al. EMBO J, 2004 May 5. PMID 15103325, Free PMC Article
  3. The SAC1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals. Vanhauwaert R, et al. EMBO J, 2017 May 15. PMID 28331029, Free PMC Article
  4. E(var)3-9 of Drosophila melanogaster encodes a zinc finger protein. Weiler KS. Genetics, 2007 Sep. PMID 17660546, Free PMC Article
  5. Copper homeostasis gene discovery in Drosophila melanogaster. Norgate M, et al. Biometals, 2007 Jun. PMID 17216353

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables phosphatidylinositol-3,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagy of peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein lipidation involved in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in phagophore assembly site membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG11975-PA
CG11975-PB
PROPPIN-3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    8993253..8995212
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275465.1 → NP_001262394.1  uncharacterized protein Dmel_CG11975, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262394.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VHJ2
    Conserved Domains (2) summary
    sd00039
    Location:102 → 136
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:141 → 265
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_141596.2 → NP_649853.1  uncharacterized protein Dmel_CG11975, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649853.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VHJ2
    Related
    FBpp0081440
    Conserved Domains (2) summary
    sd00039
    Location:102 → 136
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:141 → 265
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VHJ2 Q9VHJ2

Gene LinkOut

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