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MAGEA8 MAGE family member A8 [ Homo sapiens (human) ]

Gene ID: 4107, updated on 25-Jan-2022

Summary

Official Symbol
MAGEA8provided by HGNC
Official Full Name
MAGE family member A8provided by HGNC
Primary source
HGNC:HGNC:6806
See related
Ensembl:ENSG00000156009 MIM:300341; AllianceGenome:HGNC:6806
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT1.8; MAGE8
Summary
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2009]
Expression
Restricted expression toward placenta (RPKM 6.3) See more
Orthologs
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Genomic context

See MAGEA8 in Genome Data Viewer
Location:
Xq28
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (149881183..149885835)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (149009983..149014599)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 850 Neighboring gene deoxyuridine triphosphatase pseudogene 4 Neighboring gene MAGEA8 antisense RNA 1 Neighboring gene endothelium and lymphocyte associated ASCH domain 2 Neighboring gene heat shock transcription factor family, X-linked member 4 Neighboring gene EOLA2 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2182

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
melanoma-associated antigen 8
Names
MAGE-8 antigen
cancer/testis antigen 1.8
cancer/testis antigen family 1, member 8
melanoma antigen family A, 8
melanoma antigen family A8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_015868.1 RefSeqGene

    Range
    5043..9659
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001166400.2NP_001159872.1  melanoma-associated antigen 8

    See identical proteins and their annotated locations for NP_001159872.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 all encode the same protein.
    Source sequence(s)
    AC244099, AK313943, BC002455
    Consensus CDS
    CCDS14692.1
    UniProtKB/Swiss-Prot
    P43361
    UniProtKB/TrEMBL
    B2R9W4
    Related
    ENSP00000438293.1, ENST00000535454.5
    Conserved Domains (2) summary
    pfam01454
    Location:119283
    MAGE; MAGE family
    pfam12440
    Location:594
    MAGE_N; Melanoma associated antigen family N terminal
  2. NM_001166401.2NP_001159873.1  melanoma-associated antigen 8

    See identical proteins and their annotated locations for NP_001159873.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 all encode the same protein.
    Source sequence(s)
    AK313943, BC002455, BI092675
    Consensus CDS
    CCDS14692.1
    UniProtKB/Swiss-Prot
    P43361
    UniProtKB/TrEMBL
    B2R9W4
    Related
    ENSP00000443776.1, ENST00000542674.5
    Conserved Domains (2) summary
    pfam01454
    Location:119283
    MAGE; MAGE family
    pfam12440
    Location:594
    MAGE_N; Melanoma associated antigen family N terminal
  3. NM_005364.5NP_005355.2  melanoma-associated antigen 8

    See identical proteins and their annotated locations for NP_005355.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 all encode the same protein.
    Source sequence(s)
    AK313943, BC002455
    Consensus CDS
    CCDS14692.1
    UniProtKB/Swiss-Prot
    P43361
    UniProtKB/TrEMBL
    B2R9W4
    Related
    ENSP00000286482.1, ENST00000286482.6
    Conserved Domains (2) summary
    pfam01454
    Location:119283
    MAGE; MAGE family
    pfam12440
    Location:594
    MAGE_N; Melanoma associated antigen family N terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    149881183..149885835
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029520.1XP_016885009.1  melanoma-associated antigen 8 isoform X1

    UniProtKB/Swiss-Prot
    P43361
    Conserved Domains (2) summary
    pfam01454
    Location:119283
    MAGE; MAGE family
    pfam12440
    Location:594
    MAGE_N; Melanoma associated antigen family N terminal
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