Format

Send to:

Choose Destination

MIR17HG miR-17-92a-1 cluster host gene [ Homo sapiens (human) ]

Gene ID: 407975, updated on 9-Oct-2021

Summary

Official Symbol
MIR17HGprovided by HGNC
Official Full Name
miR-17-92a-1 cluster host geneprovided by HGNC
Primary source
HGNC:HGNC:23564
See related
Ensembl:ENSG00000215417 MIM:609415
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIHG1; MIRH1; FGLDS2; MIRHG1; C13orf25; LINC00048; miR-17-92; NCRNA00048
Summary
This gene is the host gene for the MIR17-92 cluster, a group of at least six microRNAs (miRNAs) that may be involved in cell survival, proliferation, differentiation, and angiogenesis. Amplification of this gene has been found in several lymphomas and solid tumors. Two non-protein coding transcript variants have been found for this host gene, but only the longest is a polycistronic transcript containing the MIR17-92 cluster. [provided by RefSeq, May 2012]
Expression
Ubiquitous expression in lymph node (RPKM 1.4), appendix (RPKM 1.3) and 25 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See MIR17HG in Genome Data Viewer
Location:
13q31.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (91347820..91354575)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (92000074..92006829)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370313 Neighboring gene uncharacterized LOC105370314 Neighboring gene uncharacterized LOC107984617 Neighboring gene peptidylprolyl isomerase A pseudogene 23 Neighboring gene microRNA 19b-1 Neighboring gene microRNA 92a-1 Neighboring gene microRNA 18a Neighboring gene microRNA 19a Neighboring gene microRNA 20a Neighboring gene microRNA 17 Neighboring gene glypican 5 Neighboring gene RNA, U4atac small nuclear 3, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Other Names

  • MIR17 host gene (non-protein coding)
  • long intergenic non-protein coding RNA 48
  • miR-17-92 cluster host gene (non-protein coding)
  • microRNA host gene (non-protein coding) 1
  • microRNA host gene 1 (non-protein coding)
  • mir-17-92 microRNA cluster

Clone Names

  • FLJ14178, MGC126270

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mRNA binding involved in posttranscriptional gene silencing IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cardiac right ventricle morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in gene silencing by miRNA IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lung growth ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of negative regulation of B cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cardiac muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in outflow tract morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cardiac muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of muscle hyperplasia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of B cell activation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of regulation of B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ventricular septum morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032702.1 RefSeqGene

    Range
    5001..11756
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. NR_027349.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two internal segments compared to variant 1. This transcript lacks the MIR17-92 cluster of miRNAs found in variant 1.
    Source sequence(s)
    AL138714, BC040320
    Related
    ENST00000400282.6
  2. NR_027350.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and contains the MIR17-92 cluster of miRNAs.
    Source sequence(s)
    AB176708

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    91347820..91354575
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_213723.1: Suppressed sequence

    Description
    NM_213723.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
  2. NM_213724.1: Suppressed sequence

    Description
    NM_213724.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Support Center