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CG1236 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40708, updated on 18-Sep-2024

Summary

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Official Symbol
CG1236provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0037370
Locus tag
Dmel_CG1236
See related
AllianceGenome:FB:FBgn0037370
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG1236
Summary
Predicted to enable glycerate dehydrogenase activity; glyoxylate reductase (NADP+) activity; and hydroxypyruvate reductase activity. Predicted to be active in cytosol. Is expressed in several structures, including adult head; foregut; and posterior ectoderm derivative. Human ortholog(s) of this gene implicated in primary hyperoxaluria and primary hyperoxaluria type 2. Orthologous to human GRHPR (glyoxylate and hydroxypyruvate reductase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
83C1-83C1; 3-47.5 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5736748..5738013)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1562470..1563735)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44924 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Symplekin Neighboring gene MLF1-adaptor molecule

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila Symplekin localizes dynamically to the histone locus body and tricellular junctions. Tatomer DC, et al. Nucleus, 2014. PMID 25493544, Free PMC Article
  2. Evolutionary changes in cis and trans gene regulation. Wittkopp PJ, et al. Nature, 2004 Jul 1. PMID 15229602
  3. Protein synthesis and degradation are essential to regulate germline stem cell homeostasis in Drosophila testes. Yu J, et al. Development, 2016 Aug 15. PMID 27471256
  4. Gene expression profiling identifies FKBP39 as an inhibitor of autophagy in larval Drosophila fat body. Juhász G, et al. Cell Death Differ, 2007 Jun. PMID 17363962, Free PMC Article
  5. A Genetic Screen Using the Drosophila melanogaster TRiP RNAi Collection To Identify Metabolic Enzymes Required for Eye Development. Pletcher RC, et al. G3 (Bethesda), 2019 Jul 9. PMID 31036678, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables glyoxylate reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydroxypyruvate reductase (NADH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG1236-PA
NP_649579.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    5736748..5738013
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141322.2 → NP_649579.2  uncharacterized protein Dmel_CG1236 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649579.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I725, Q8MR05
    Related
    FBpp0078370
    Conserved Domains (2) summary
    COG1052
    Location:27 → 338
    LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
    cd05301
    Location:27 → 338
    GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8I725 Q8I725
Q8MR05 Q8MR05

Gene LinkOut

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