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MIR24-1 microRNA 24-1 [ Homo sapiens (human) ]

Gene ID: 407012, updated on 9-Oct-2022

Summary

Official Symbol
MIR24-1provided by HGNC
Official Full Name
microRNA 24-1provided by HGNC
Primary source
HGNC:HGNC:31607
See related
Ensembl:ENSG00000284459 MIM:609705; miRBase:MI0000080; AllianceGenome:HGNC:31607
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIR189; MIRN24-1; miR-24-1; miRNA24-1
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

See MIR24-1 in Genome Data Viewer
Location:
9q22.32
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (95086021..95086088)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (107255414..107255481)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (97848303..97848370)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene aminopeptidase O (putative) Neighboring gene uncharacterized LOC107987102 Neighboring gene microRNA 3074 Neighboring gene microRNA 23b Neighboring gene microRNA 27b Neighboring gene FA complementation group C Neighboring gene ribosomal protein S26 pseudogene 37

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Other Names

  • hsa-mir-24-1
  • microRNA-24

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell growth involved in cardiac muscle cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in miRNA-mediated gene silencing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in miRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
 
involved_in miRNA-mediated gene silencing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in miRNA-mediated gene silencing by inhibition of translation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of amyloid-beta formation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of blood vessel endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cardiac muscle cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of fibroblast apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of macrophage migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of metalloendopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of sodium ion import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of negative regulation of type II interferon production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of vascular endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of voltage-gated sodium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of endothelial cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of reactive oxygen species biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of vascular associated smooth muscle cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_029496.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AL354893
    Related
    ENST00000637495.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    95086021..95086088
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    107255414..107255481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)