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TACSTD2 tumor associated calcium signal transducer 2 [ Homo sapiens (human) ]

Gene ID: 4070, updated on 2-Nov-2024

Summary

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Official Symbol
TACSTD2provided by HGNC
Official Full Name
tumor associated calcium signal transducer 2provided by HGNC
Primary source
HGNC:HGNC:11530
See related
Ensembl:ENSG00000184292 MIM:137290; AllianceGenome:HGNC:11530
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1
Summary
This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]
Orthologs
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Genomic context

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See TACSTD2 in Genome Data Viewer
Location:
1p32.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (58575433..58577252, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (58453397..58455216, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (59041105..59042924, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene DAB adaptor protein 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:59011807-59012433 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1083 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1084 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1085 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:59041692-59042387 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:59042388-59043082 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:59049763-59050962 Neighboring gene Sharpr-MPRA regulatory region 6655 Neighboring gene Sharpr-MPRA regulatory region 14294 Neighboring gene RNA, 7SL, cytoplasmic 713, pseudogene Neighboring gene Sharpr-MPRA regulatory region 3519 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1087 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1086 Neighboring gene OMA1 zinc metallopeptidase Neighboring gene adenylate kinase 2 pseudogene 1 Neighboring gene Myb like, SWIRM and MPN domains 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tumor-associated calcium signal transducer 2 regulates neovascularization of non-small-cell lung cancer via activating ERK1/2 signaling pathway. Guo X, et al. Tumour Biol, 2017 Mar. PMID 28345466
  2. [Expression of TROP2 mRNA in left-sided and right-sided colon cancer and its clinical significance]. Xu KY, et al. Zhonghua Wei Chang Wai Ke Za Zhi, 2009 May. PMID 19434540
  3. Prognostic value of TROP2 in human nasopharyngeal carcinoma. Guan GF, et al. Int J Clin Exp Pathol, 2015. PMID 26617817, Free PMC Article
  4. Suppression of trophoblast cell surface antigen 2 enhances proliferation and migration in liver fluke-associated cholangiocarcinoma. Sawanyawisuth K, et al. Ann Hepatol, 2016 Jan-Feb. PMID 26626643
  5. Trop2 is overexpressed in gastric cancer and predicts poor prognosis. Zhao W, et al. Oncotarget, 2016 Feb 2. PMID 26716416, Free PMC Article

See all (171) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TROP2 Expression and Therapeutic Implications in Cutaneous Squamous Cell Carcinoma: Insights From Immunohistochemical and Functional Analysis.
    Title: TROP2 Expression and Therapeutic Implications in Cutaneous Squamous Cell Carcinoma: Insights From Immunohistochemical and Functional Analysis.
  2. TROP2 in colorectal carcinoma: associations with histopathology, molecular phenotype, and patient prognosis.
    Title: TROP2 in colorectal carcinoma: associations with histopathology, molecular phenotype, and patient prognosis.
  3. Trop-2 expression and the tumor immune microenvironment in cervical cancer.
    Title: Trop-2 expression and the tumor immune microenvironment in cervical cancer.
  4. Unveiling the placental secrets: Exploring histopathological changes and TROP2 expression in intrahepatic cholestasis of pregnancy.
    Title: Unveiling the placental secrets: Exploring histopathological changes and TROP2 expression in intrahepatic cholestasis of pregnancy.
  5. TROP2 promotes PINK1-mediated mitophagy and apoptosis to accelerate the progression of senile chronic obstructive pulmonary disease by up-regulating DRP1 expression.
    Title: TROP2 promotes PINK1-mediated mitophagy and apoptosis to accelerate the progression of senile chronic obstructive pulmonary disease by up-regulating DRP1 expression.
  6. Diagnostic and prognostic utility of TROP-2, SLP-2, and CXCL12 expression in papillary thyroid carcinoma.
    Title: Diagnostic and prognostic utility of TROP-2, SLP-2, and CXCL12 expression in papillary thyroid carcinoma.
  7. Associations of TACSTD2/TROP2 and NECTIN-4/NECTIN-4 with molecular subtypes, PD-L1 expression, and FGFR3 mutational status in two advanced urothelial bladder cancer cohorts.
    Title: Associations of TACSTD2/TROP2 and NECTIN-4/NECTIN-4 with molecular subtypes, PD-L1 expression, and FGFR3 mutational status in two advanced urothelial bladder cancer cohorts.
  8. TROP2 Is Associated with Primary Resistance to Immune Checkpoint Inhibition in Patients with Advanced Non-Small Cell Lung Cancer.
    Title: TROP2 Is Associated with Primary Resistance to Immune Checkpoint Inhibition in Patients with Advanced Non-Small Cell Lung Cancer.
  9. DNA demethylation and tri-methylation of H3K4 at the TACSTD2 promoter are complementary players for TROP2 regulation in colorectal cancer cells.
    Title: DNA demethylation and tri-methylation of H3K4 at the TACSTD2 promoter are complementary players for TROP2 regulation in colorectal cancer cells.
  10. Trop-2 Is Highly Expressed in Early Luminal-Like Breast Cancer.
    Title: Trop-2 Is Highly Expressed in Early Luminal-Like Breast Cancer.
Submit: New GeneRIF Correction See all GeneRIFs (136)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Gelatinous droplike corneal dystrophy
MedGen: C0339273 OMIM: 204870 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of branching involved in ureteric bud morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cell motility ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of epithelial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of ruffle assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of stress fiber assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of substrate adhesion-dependent cell spreading ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of stem cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basal plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tumor-associated calcium signal transducer 2
Names
40kD glycoprotein, identified by monoclonal antibody GA733
cell surface glycoprotein TROP2
cell surface glycoprotein Trop-2
epithelial glycoprotein-1
gastrointestinal tumor-associated antigen GA7331
membrane component, chromosome 1, surface marker 1
pancreatic carcinoma marker protein GA733-1
pancreatic carcinoma marker protein GA7331
trophoblast cell surface antigen 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016237.1 RefSeqGene

    Range
    5243..7062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002353.3 → NP_002344.2  tumor-associated calcium signal transducer 2 precursor

    See identical proteins and their annotated locations for NP_002344.2

    Status: REVIEWED

    Source sequence(s)
    AI201870, AW052118, BM765888, CD722224, CV027795
    Consensus CDS
    CCDS609.1
    UniProtKB/Swiss-Prot
    P09758, Q15658, Q6FG48, Q7Z7Q4, Q96QD2
    UniProtKB/TrEMBL
    C5IX07
    Related
    ENSP00000360269.2, ENST00000371225.4
    Conserved Domains (1) summary
    cd00191
    Location:72 → 145
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    58575433..58577252 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    58453397..58455216 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P09758.3 GenPept UniProtKB/Swiss-Prot:P09758

Gene LinkOut

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Chemical Information
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