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MIR185 microRNA 185 [ Homo sapiens (human) ]

Gene ID: 406961, updated on 30-Oct-2022

Summary

Official Symbol
MIR185provided by HGNC
Official Full Name
microRNA 185provided by HGNC
Primary source
HGNC:HGNC:31556
See related
Ensembl:ENSG00000208023 MIM:615576; miRBase:MI0000482; AllianceGenome:HGNC:31556
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIRN185; miR-185
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

See MIR185 in Genome Data Viewer
Location:
22q11.21
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (20033139..20033220)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (20410752..20410833)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (20020662..20020743)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene catechol-O-methyltransferase Neighboring gene microRNA 4761 Neighboring gene ARVCF delta catenin family member Neighboring gene uncharacterized LOC124905082 Neighboring gene transport and golgi organization 2 homolog Neighboring gene DGCR8 microprocessor complex subunit Neighboring gene microRNA 3618 Neighboring gene microRNA 1306

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Other Names

  • hsa-mir-185

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cellular response to cholesterol IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cholesterol homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in miRNA-mediated gene silencing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in miRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
 
involved_in miRNA-mediated gene silencing IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of (R)-mevalonic acid biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of negative regulation of B cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of advanced glycation end-product receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of cholesterol biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of low-density lipoprotein particle clearance IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of low-density lipoprotein particle clearance IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of negative regulation of low-density lipoprotein receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of vascular associated smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of xenobiotic detoxification by transmembrane export across the plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of macrophage derived foam cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_029706.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC005663
    Related
    ENST00000385288.3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    20033139..20033220
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    20410752..20410833
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)