Format

Send to:

Choose Destination

MIR181B1 microRNA 181b-1 [ Homo sapiens (human) ]

Gene ID: 406955, updated on 2-Mar-2021

Summary

Official Symbol
MIR181B1provided by HGNC
Official Full Name
microRNA 181b-1provided by HGNC
Primary source
HGNC:HGNC:31550
See related
Ensembl:ENSG00000207975 MIM:612744; miRBase:MI0000270
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIRN181B1; mir-181b-1
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See MIR181B1 in Genome Data Viewer
Location:
1q32.1
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (198858873..198858982, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (198828002..198828111, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase receptor type C Neighboring gene PTPRC intron CAGE-defined mid-level expression enhancer Neighboring gene phosphatidylethanolamine binding protein 1 pseudogene 3 Neighboring gene MIR181A1 host gene Neighboring gene microRNA 181a-1 Neighboring gene ribosomal protein S2 pseudogene 9

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Other Names

  • hsa-mir-181b-1

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cellular response to tumor necrosis factor ISS
Inferred from Sequence or Structural Similarity
more info
 
gene silencing by miRNA IDA
Inferred from Direct Assay
more info
PubMed 
gene silencing by miRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
miRNA mediated inhibition of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of astrocyte activation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of defense response to bacterium IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of innate immune response IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of keratinocyte proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of mitochondrial membrane potential ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of phagocytosis IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of toll-like receptor 4 signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of elastin catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of endothelial cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of fibroblast apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of inflammatory response IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of macrophage proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of nitric oxide biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of p38MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
extracellular space HDA PubMed 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_029612.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AL136321
    Related
    ENST00000385240.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    198858873..198858982 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center