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MIR106A microRNA 106a [ Homo sapiens (human) ]

Gene ID: 406899, updated on 22-Sep-2022

Summary

Official Symbol
MIR106Aprovided by HGNC
Official Full Name
microRNA 106aprovided by HGNC
Primary source
HGNC:HGNC:31494
See related
Ensembl:ENSG00000284157 MIM:300792; miRBase:MI0000113; AllianceGenome:HGNC:31494
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
mir-106; MIRN106A; mir-106a
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

See MIR106A in Genome Data Viewer
Location:
Xq26.2
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (134170198..134170278, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (132495345..132495425, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (133304228..133304308, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124905221 Neighboring gene microRNA 20b Neighboring gene microRNA 18b Neighboring gene LARP1B pseudogene 3 Neighboring gene coiled-coil domain containing 160

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Other Names

  • hsa-mir-106a

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in miRNA-mediated gene silencing HDA PubMed 
involved_in miRNA-mediated gene silencing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in miRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
 
involved_in miRNA-mediated gene silencing by inhibition of translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in miRNA-mediated gene silencing by mRNA destabilization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of BMP secretion IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of amyloid precursor protein biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of interleukin-10 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of interleukin-10 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of interleukin-10 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-10 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of interleukin-8 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of osteoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of vascular endothelial growth factor production HMP PubMed 
acts_upstream_of_or_within positive regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of RISC complex IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular vesicle HDA PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_029523.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC002407
    Related
    ENST00000384870.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    134170198..134170278 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    132495345..132495425 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)