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abcd3a ATP-binding cassette, sub-family D (ALD), member 3a [ Danio rerio (zebrafish) ]

Gene ID: 406803, updated on 2-Nov-2024

Summary

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Official Symbol
abcd3aprovided by ZNC
Official Full Name
ATP-binding cassette, sub-family D (ALD), member 3aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2868
See related
Ensembl:ENSDARG00000104085 AllianceGenome:ZFIN:ZDB-GENE-040426-2868
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb59g09; fd60b04; zgc:55740; wu:fb59g09; wu:fd60b04
Summary
Predicted to enable ATP binding activity; ATPase-coupled transmembrane transporter activity; and long-chain fatty acid transmembrane transporter activity. Predicted to be involved in fatty acid catabolic process; long-chain fatty acid import into peroxisome; and peroxisome organization. Predicted to act upstream of or within transmembrane transport. Predicted to be located in membrane and peroxisome. Predicted to be active in peroxisomal membrane. Human ortholog(s) of this gene implicated in Zellweger syndrome and congenital bile acid synthesis defect 5. Orthologous to human ABCD3 (ATP binding cassette subfamily D member 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See abcd3a in Genome Data Viewer
Location:
chromosome: 24
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (31310640..31332087, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (31373429..31394876, complement)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene coagulation factor IIIa Neighboring gene acid phosphatase 5b, tartrate resistant Neighboring gene family with sequence similarity 168 member B Neighboring gene cAMP responsive element modulator b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Enoyl-CoA hydratase/3-hydroxyacyl CoA dehydrogenase is essential for the production of DHA in zebrafish. Yang G, et al. J Lipid Res, 2023 Mar. PMID 36592657, Free PMC Article
  2. Evolution of the vertebrate ABC gene family: analysis of gene birth and death. Annilo T, et al. Genomics, 2006 Jul. PMID 16631343
  3. Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates. Dean M, et al. Annu Rev Genomics Hum Genet, 2005. PMID 16124856
  4. Genome-wide analysis of the ATP-binding cassette (ABC) transporter gene family in sea lamprey and Japanese lamprey. Ren J, et al. BMC Genomics, 2015 Jun 6. PMID 26047617, Free PMC Article
  5. Functional Characterization and Expression Analyses Show Differential Roles of Maternal and Zygotic Dgcr8 in Early Embryonic Development. Zhu Z, et al. Front Genet, 2020. PMID 32296464, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase-coupled transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables long-chain fatty acid transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty acid import into peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within long-chain fatty acid import into peroxisome IEA
Inferred from Electronic Annotation
more info
  
involved_in peroxisome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in very long-chain fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATP-binding cassette sub-family D member 3a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213482.1 → NP_998647.1  ATP-binding cassette sub-family D member 3a

    See identical proteins and their annotated locations for NP_998647.1

    Status: PROVISIONAL

    Source sequence(s)
    BC044468
    UniProtKB/TrEMBL
    Q803I6
    Related
    ENSDARP00000138371.1, ENSDART00000161179.2
    Conserved Domains (3) summary
    cd03223
    Location:437 → 642
    ABCD_peroxisomal_ALDP; ATP-binding cassette domain of peroxisomal transporter, subfamily D
    TIGR00954
    Location:1 → 644
    3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein
    pfam06472
    Location:58 → 337
    ABC_membrane_2; ABC transporter transmembrane region 2

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    31310640..31332087 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021470125.2 → XP_021325800.1  ATP-binding cassette sub-family D member 3a isoform X1

    UniProtKB/TrEMBL
    A0A8M9PXC6
    Conserved Domains (1) summary
    TIGR00954
    Location:1 → 644
    3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395182.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    138973..160023 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395367.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    140369..164922 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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