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LTC4S leukotriene C4 synthase [ Homo sapiens (human) ]

Gene ID: 4056, updated on 5-Nov-2017
Official Symbol
LTC4Sprovided by HGNC
Official Full Name
leukotriene C4 synthaseprovided by HGNC
Primary source
HGNC:HGNC:6719
See related
Ensembl:ENSG00000213316 MIM:246530; Vega:OTTHUMG00000150314
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 3.3), lung (RPKM 2.5) and 23 other tissues See more
Orthologs
Location:
5q35.3
Exon count:
5
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 5 NC_000005.10 (179793985..179796512)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (179219263..179223616)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene mastermind like transcriptional coactivator 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit A12 pseudogene Neighboring gene microRNA 1229 Neighboring gene mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B Neighboring gene sequestosome 1 Neighboring gene MRN complex interacting protein

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Arachidonic acid metabolism, organism-specific biosystem (from KEGG)
    Arachidonic acid metabolism, organism-specific biosystem
    Arachidonic acid metabolism
  • Arachidonic acid metabolism, organism-specific biosystem (from REACTOME)
    Arachidonic acid metabolism, organism-specific biosystemEicosanoids, oxygenated, 20-carbon fatty acids, are autocrine and paracrine signaling molecules that modulate physiological processes including pain, fever, inflammation, blood clot formation, smooth...
  • Arachidonic acid metabolism, conserved biosystem (from KEGG)
    Arachidonic acid metabolism, conserved biosystem
    Arachidonic acid metabolism
  • Eicosanoid Synthesis, organism-specific biosystem (from WikiPathways)
    Eicosanoid Synthesis, organism-specific biosystemIn biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or i...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Synthesis of 5-eicosatetraenoic acids, organism-specific biosystem (from REACTOME)
    Synthesis of 5-eicosatetraenoic acids, organism-specific biosystem5-hydroperoxy-eicosatetraenoic acid (5-HpETE), 5-hydroxyeicosatetraenoic acid (5S-HETE) and 5-oxo-eicosatetraenoic acid (5-oxoETE) are formed after the initial step of arachidonic acid oxidation by ...
  • Synthesis of Leukotrienes (LT) and Eoxins (EX), organism-specific biosystem (from REACTOME)
    Synthesis of Leukotrienes (LT) and Eoxins (EX), organism-specific biosystemLeukotrienes (LTs) are biologically active molecules formed in response to inflammatory stimuli. They cause contraction of bronchial smooth muscles, stimulation of vascular permeability, and attracti...
  • Synthesis of Lipoxins (LX), organism-specific biosystem (from REACTOME)
    Synthesis of Lipoxins (LX), organism-specific biosystemLipoxins A4 (LXA4) and B4 (LXB4), structurally characterized from human neutrophils incubated with 15-hydroperoxy-eicosatetraenoic acid (15-HpETE), each contain three hydroxyl moieties and a conjugat...
  • leukotriene biosynthesis, organism-specific biosystem (from BIOCYC)
    leukotriene biosynthesis, organism-specific biosystemLeukotrienes are made by cells of the immune system, mainly the mediators of inflammation like polymorphonuclear leukocytes, macrophages and mast cells. Cellular activation during inflammation leads ...
  • leukotriene biosynthesis, conserved biosystem (from BIOCYC)
    leukotriene biosynthesis, conserved biosystemLeukotrienes are proinflammatory metabolites of arachidonic acid that activate and amplify innate and adaptive immune responses. They also have roles in pathologic immune responses, mediating contrac...
Products Interactant Other Gene Complex Source Pubs Description

Homology

Clone Names

  • MGC33147

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme activator activity IEA
Inferred from Electronic Annotation
more info
 
glutathione peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
leukotriene-C4 synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
lipid binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
leukotriene biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
leukotriene metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
leukotriene metabolic process TAS
Traceable Author Statement
more info
 
lipoxin metabolic process TAS
Traceable Author Statement
more info
 
lipoxygenase pathway TAS
Traceable Author Statement
more info
 
positive regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle TAS
Traceable Author Statement
more info
PubMed 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope TAS
Traceable Author Statement
more info
 
nuclear outer membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
leukotriene C4 synthase
Names
LTC4 synthase
NP_665874.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028161.1 RefSeqGene

    Range
    5001..7528
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_145867.1NP_665874.1  leukotriene C4 synthase

    See identical proteins and their annotated locations for NP_665874.1

    Status: REVIEWED

    Source sequence(s)
    BC029498
    Consensus CDS
    CCDS34316.1
    UniProtKB/Swiss-Prot
    Q16873
    Related
    ENSP00000292596.10, OTTHUMP00000197039, ENST00000292596.14, OTTHUMT00000317536
    Conserved Domains (1) summary
    pfam01124
    Location:8100
    MAPEG; MAPEG family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p7 Primary Assembly

    Range
    179793985..179796512
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 Alternate CHM1_1.1

    Range
    178653394..178655921
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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