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LTA4H leukotriene A4 hydrolase [ Homo sapiens (human) ]

Gene ID: 4048, updated on 4-Oct-2020

Summary

Official Symbol
LTA4Hprovided by HGNC
Official Full Name
leukotriene A4 hydrolaseprovided by HGNC
Primary source
HGNC:HGNC:6710
See related
Ensembl:ENSG00000111144 MIM:151570
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in lung (RPKM 63.8), bone marrow (RPKM 53.7) and 25 other tissues See more
Orthologs

Genomic context

See LTA4H in Genome Data Viewer
Location:
12q23.1
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (96000753..96043520, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (96394531..96437298, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene amidohydrolase domain containing 1 Neighboring gene AMDHD1 eExon liver enhancer Neighboring gene histidine ammonia-lyase Neighboring gene uncharacterized LOC102723340 Neighboring gene tRNA-Asp (anticodon GTC) 2-8 Neighboring gene YPEL5 pseudogene 3 Neighboring gene uncharacterized LOC105369923 Neighboring gene RNA, 7SL, cytoplasmic 88, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ17564

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
aminopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
epoxide hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
epoxide hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
epoxide hydrolase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
epoxide hydrolase activity TAS
Traceable Author Statement
more info
PubMed 
leukotriene-A4 hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
leukotriene-A4 hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
metalloaminopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidase activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
cellular lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular protein metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
leukotriene biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
leukotriene biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
leukotriene biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
leukotriene metabolic process TAS
Traceable Author Statement
more info
 
long-chain fatty acid biosynthetic process TAS
Traceable Author Statement
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
peptide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tertiary granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
leukotriene A-4 hydrolase
Names
LTA-4 hydrolase
testicular secretory protein Li 27
NP_000886.1
NP_001243572.1
NP_001243573.1
XP_005268928.1
XP_011536651.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000895.3NP_000886.1  leukotriene A-4 hydrolase isoform 1

    See identical proteins and their annotated locations for NP_000886.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    J03459, R41544
    Consensus CDS
    CCDS9059.1
    UniProtKB/Swiss-Prot
    P09960
    UniProtKB/TrEMBL
    A0A140VK27
    Related
    ENSP00000228740.2, ENST00000228740.7
    Conserved Domains (1) summary
    TIGR02411
    Location:6608
    leuko_A4_hydro; leukotriene A-4 hydrolase/aminopeptidase
  2. NM_001256643.1NP_001243572.1  leukotriene A-4 hydrolase isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    BC032528, BX647158, DC358373, R41544
    Consensus CDS
    CCDS58267.1
    UniProtKB/Swiss-Prot
    P09960
    Related
    ENSP00000449958.1, ENST00000552789.5
    Conserved Domains (3) summary
    cd09599
    Location:30426
    M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase
    TIGR02411
    Location:30584
    leuko_A4_hydro; leukotriene A-4 hydrolase/aminopeptidase
    pfam09127
    Location:444583
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
  3. NM_001256644.1NP_001243573.1  leukotriene A-4 hydrolase isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, initiates translation at an alternate start codon and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AK298017, AK308184, R41544
    Consensus CDS
    CCDS58266.1
    UniProtKB/Swiss-Prot
    P09960
    Related
    ENSP00000395051.2, ENST00000413268.6
    Conserved Domains (2) summary
    cd09599
    Location:30426
    M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase
    pfam09127
    Location:444492
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal

RNA

  1. NR_132659.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses two alternate splice junctions compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC007298, AI582379, AK293630, AK298017, R41544

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    96000753..96043520 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268871.2XP_005268928.1  leukotriene A-4 hydrolase isoform X1

    See identical proteins and their annotated locations for XP_005268928.1

    UniProtKB/Swiss-Prot
    P09960
    Conserved Domains (1) summary
    cl28130
    Location:6514
    Peptidase_M1; Peptidase family M1
  2. XM_011538349.3XP_011536651.1  leukotriene A-4 hydrolase isoform X2

    Conserved Domains (2) summary
    cd09599
    Location:6450
    M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase
    pfam01433
    Location:21387
    Peptidase_M1; Peptidase family M1

RNA

  1. XR_002957326.1 RNA Sequence

  2. XR_001748703.2 RNA Sequence

    Related
    ENST00000548852.5
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