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ANKHD1-EIF4EBP3 ANKHD1-EIF4EBP3 readthrough [ Homo sapiens (human) ]

Gene ID: 404734, updated on 23-Nov-2021

Summary

Official Symbol
ANKHD1-EIF4EBP3provided by HGNC
Official Full Name
ANKHD1-EIF4EBP3 readthroughprovided by HGNC
Primary source
HGNC:HGNC:33530
See related
Ensembl:ENSG00000254996
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MASK-BP3; MASK-BP3ARF
Summary
The ANKHD1-EIF4EBP3 mRNA is an infrequent but naturally occurring readthrough transcript of the neighboring ANKHD1 and EIF4EBP3 genes. This readthrough transcript encodes a protein composed mostly of the multiple ankyrin repeats, single KH-domain protein, with its C-terminus encoded in a different reading frame from the shared portion of the EIF4EBP3 gene. The significance of this readthrough mRNA and the function of its protein product have not yet been determined. [provided by RefSeq, Nov 2009]
Expression
Ubiquitous expression in thyroid (RPKM 19.9), skin (RPKM 16.1) and 25 other tissues See more
Orthologs
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Genomic context

See ANKHD1-EIF4EBP3 in Genome Data Viewer
Location:
5q31.3
Exon count:
36
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (140401833..140549576)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (139781418..139929161)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 4 member 9 Neighboring gene RNA, U4 small nuclear 14, pseudogene Neighboring gene ankyrin repeat and KH domain containing 1 Neighboring gene eukaryotic translation initiation factor 4E binding protein 3 Neighboring gene steroid receptor RNA activator 1 Neighboring gene microRNA 6831 Neighboring gene amyloid beta precursor protein binding family B member 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
ANKHD1-EIF4EBP3 protein
Names
MASK-4E-BP3 alternate reading frame

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020690.6NP_065741.3  ANKHD1-EIF4EBP3 protein

    See identical proteins and their annotated locations for NP_065741.3

    Status: REVIEWED

    Source sequence(s)
    AC008438, AC011399, AF521883
    Consensus CDS
    CCDS4224.1
    UniProtKB/Swiss-Prot
    Q8IWZ3
    Related
    ENSP00000432016.1, ENST00000532219.5
    Conserved Domains (7) summary
    cd00105
    Location:16971759
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd00204
    Location:367491
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam05672
    Location:780865
    MAP7; MAP7 (E-MAP-115) family
    pfam12796
    Location:276365
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:374425
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:406435
    ANK; ANK repeat [structural motif]
    cl09111
    Location:814852
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    140401833..140549576
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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