Mrgpra5 MAS-related GPR, member A5 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Mrgpra5provided by MGI
Official Full Name: MAS-related GPR, member A5provided by MGI
Primary source: MGI:MGI:3033102
See related: AllianceGenome:MGI:3033102
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MrgA5
Summary: Predicted to enable G protein-coupled receptor activity and neuropeptide binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway; mast cell degranulation; and positive regulation of cytokinesis. Predicted to act upstream of or within signal transduction. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Orthologous to several human genes including MRGPRX1 (MAS related GPR family member X1); MRGPRX2 (MAS related GPR family member X2); and MRGPRX3 (MAS related GPR family member X3). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: not in current annotation release
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Genomic context

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Location:: 7 B3; 7 30.88 cM

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables neuropeptide binding	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in mast cell activation	ISO Inferred from Sequence Orthology more info
involved_in mast cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: mas-related G-protein coupled receptor member A5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_207534.1 → NP_997417.1 mas-related G-protein coupled receptor member A5

See identical proteins and their annotated locations for NP_997417.1

Status: PROVISIONAL

Source sequence(s)

AY042195

UniProtKB/Swiss-Prot

Q91ZC7

Conserved Domains (1) summary

pfam00001
Location:12 → 244

7tm_1; 7 transmembrane receptor (rhodopsin family)