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APOBEC4 apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4 [ Homo sapiens (human) ]

Gene ID: 403314, updated on 1-Aug-2020

Summary

Official Symbol
APOBEC4provided by HGNC
Official Full Name
apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4provided by HGNC
Primary source
HGNC:HGNC:32152
See related
Ensembl:ENSG00000173627 MIM:609908
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C1orf169
Summary
This gene encodes a member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases, which convert cytidine to uridine. Other AID/APOBEC family members are involved in mRNA editing, somatic hypermutation and recombination of immunoglobulin genes, and innate immunity to retroviral infection. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 6.1) See more
Orthologs

Genomic context

See APOBEC4 in Genome Data Viewer
Location:
1q25.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (183646275..183653316, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (183615410..183622448, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NCF2-ARPC5 intergenic ENCODE-defined enhancer Neighboring gene actin related protein 2/3 complex subunit 5 Neighboring gene ral guanine nucleotide dissociation stimulator like 1 Neighboring gene T-box transcription factor T pseudogene Neighboring gene collagen beta(1-O)galactosyltransferase 2 Neighboring gene NFE2L2 motif-containing MPRA enhancer 281

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC26594

Gene Ontology Provided by GOA

Function Evidence Code Pubs
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
mRNA processing IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
putative C->U-editing enzyme APOBEC-4
Names
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
NP_982279.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_203454.3NP_982279.1  putative C->U-editing enzyme APOBEC-4

    See identical proteins and their annotated locations for NP_982279.1

    Status: REVIEWED

    Source sequence(s)
    AI961390, AL137800, BC021711
    Consensus CDS
    CCDS1358.1
    UniProtKB/Swiss-Prot
    Q8WW27
    Related
    ENSP00000310622.4, ENST00000308641.6
    Conserved Domains (1) summary
    pfam08210
    Location:47213
    APOBEC_N; APOBEC-like N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    183646275..183653316 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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