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IRAG2 inositol 1,4,5-triphosphate receptor associated 2 [ Homo sapiens (human) ]

Gene ID: 4033, updated on 8-Jul-2021

Summary

Official Symbol
IRAG2provided by HGNC
Official Full Name
inositol 1,4,5-triphosphate receptor associated 2provided by HGNC
Primary source
HGNC:HGNC:6690
See related
Ensembl:ENSG00000118308 MIM:602003
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JAW1; LRMP
Summary
The protein encode dby this gene is expressed in a developmentally regulated manner in lymphoid cell lines and tissues. The protein is localized to the cytoplasmic face of the endoplasmic reticulum. [provided by RefSeq, Jul 2008]
Expression
Biased expression in lymph node (RPKM 77.5), appendix (RPKM 26.1) and 5 other tissues See more
Orthologs
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Genomic context

See IRAG2 in Genome Data Viewer
Location:
12p12.1
Exon count:
42
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (24997575..25108335)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (25205162..25261269)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene brain protein I3 pseudogene 2 Neighboring gene long intergenic non-protein coding RNA 2909 Neighboring gene centromere protein U pseudogene 2 Neighboring gene dynein axonemal intermediate chain 7 Neighboring gene electron transfer flavoprotein regulatory factor 1 Neighboring gene KRAS proto-oncogene, GTPase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleus organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in single fertilization IEA
Inferred from Electronic Annotation
more info
 
involved_in vesicle fusion TAS
Traceable Author Statement
more info
PubMed 
involved_in vesicle targeting TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in azurophil granule membrane TAS
Traceable Author Statement
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in membrane HDA PubMed 
located_in microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear envelope ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
inositol 1,4,5-triphosphate receptor associated 2
Names
lymphoid restricted membrane protein
protein Jaw1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204126.2NP_001191055.1  inositol 1,4,5-triphosphate receptor associated 2 isoform a

    See identical proteins and their annotated locations for NP_001191055.1

    Status: REVIEWED

    Source sequence(s)
    AC023510, AW206014, BC144164, DB135324
    Consensus CDS
    CCDS8701.1
    UniProtKB/Swiss-Prot
    Q12912
    Related
    ENSP00000450246.1, ENST00000547044.5
    Conserved Domains (1) summary
    pfam05781
    Location:1499
    MRVI1; MRVI1 protein
  2. NM_001204127.2NP_001191056.1  inositol 1,4,5-triphosphate receptor associated 2 isoform a

    See identical proteins and their annotated locations for NP_001191056.1

    Status: REVIEWED

    Source sequence(s)
    AC023510, AK303256, AW206014
    Consensus CDS
    CCDS8701.1
    UniProtKB/Swiss-Prot
    Q12912
    Related
    ENSP00000446496.1, ENST00000548766.5
    Conserved Domains (1) summary
    pfam05781
    Location:1499
    MRVI1; MRVI1 protein
  3. NM_001366540.1NP_001353469.1  inositol 1,4,5-triphosphate receptor associated 2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC023510
    Conserved Domains (1) summary
    pfam05781
    Location:1499
    MRVI1; MRVI1 protein
  4. NM_001366541.2NP_001353470.1  inositol 1,4,5-triphosphate receptor associated 2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC023510
    Conserved Domains (1) summary
    pfam05781
    Location:1499
    MRVI1; MRVI1 protein
  5. NM_001366542.2NP_001353471.1  inositol 1,4,5-triphosphate receptor associated 2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC023510
    Conserved Domains (1) summary
    pfam05781
    Location:1499
    MRVI1; MRVI1 protein
  6. NM_001366543.2NP_001353472.1  inositol 1,4,5-triphosphate receptor associated 2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC023510
    Conserved Domains (1) summary
    pfam05781
    Location:1499
    MRVI1; MRVI1 protein
  7. NM_001366544.2NP_001353473.1  inositol 1,4,5-triphosphate receptor associated 2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC023510
    Related
    ENST00000549437.5
    Conserved Domains (1) summary
    pfam05781
    Location:1499
    MRVI1; MRVI1 protein
  8. NM_001366545.2NP_001353474.1  inositol 1,4,5-triphosphate receptor associated 2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC023510
    Conserved Domains (1) summary
    pfam05781
    Location:1499
    MRVI1; MRVI1 protein
  9. NM_001366546.2NP_001353475.1  inositol 1,4,5-triphosphate receptor associated 2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC023510
    Conserved Domains (1) summary
    pfam05781
    Location:1499
    MRVI1; MRVI1 protein
  10. NM_001366547.2NP_001353476.1  inositol 1,4,5-triphosphate receptor associated 2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC023510
    Conserved Domains (1) summary
    pfam05781
    Location:1499
    MRVI1; MRVI1 protein
  11. NM_001366548.2NP_001353477.1  inositol 1,4,5-triphosphate receptor associated 2 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC023510
    Conserved Domains (1) summary
    pfam05781
    Location:1425
    MRVI1; MRVI1 protein
  12. NM_001366549.2NP_001353478.1  inositol 1,4,5-triphosphate receptor associated 2 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC023510
    Related
    ENSP00000444056.1, ENST00000536173.5
    Conserved Domains (1) summary
    pfam05781
    Location:1446
    MRVI1; MRVI1 protein
  13. NM_001394803.1NP_001381732.1  inositol 1,4,5-triphosphate receptor associated 2 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC023510
  14. NM_006152.4NP_006143.2  inositol 1,4,5-triphosphate receptor associated 2 isoform a

    See identical proteins and their annotated locations for NP_006143.2

    Status: REVIEWED

    Source sequence(s)
    AC023510, AW206014, BC126417, DB135324
    Consensus CDS
    CCDS8701.1
    UniProtKB/Swiss-Prot
    Q12912
    Related
    ENSP00000346442.3, ENST00000354454.7
    Conserved Domains (1) summary
    pfam05781
    Location:1499
    MRVI1; MRVI1 protein

RNA

  1. NR_159366.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC023510
  2. NR_159367.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC023510
    Related
    ENST00000361433.6
  3. NR_159368.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC023510
  4. NR_159369.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC023510

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    24997575..25108335
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001321724.3: Suppressed sequence

    Description
    NM_001321724.3: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
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