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XKRX XK related X-linked [ Homo sapiens (human) ]

Gene ID: 402415, updated on 11-Jun-2021

Summary

Official Symbol
XKRXprovided by HGNC
Official Full Name
XK related X-linkedprovided by HGNC
Primary source
HGNC:HGNC:29845
See related
Ensembl:ENSG00000182489 MIM:300684
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
XKR2; XRG2; XPLAC
Summary
This gene encodes a protein that is related to a component of the XK/Kell complex of the Kell blood group system. The encoded protein includes several transmembrane domains, is known to be exposed to the cell surface, and may function as a membrane transporter. [provided by RefSeq, May 2010]
Expression
Broad expression in skin (RPKM 2.6), lymph node (RPKM 0.8) and 19 other tissues See more
Orthologs
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Genomic context

See XKRX in Genome Data Viewer
Location:
Xq22.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (100886919..100957401, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (100168434..100183906, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene cleavage stimulation factor subunit 2 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 26 Neighboring gene NADPH oxidase 1 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 27 Neighboring gene NSA2 pseudogene 3 Neighboring gene CSGALNACT2 pseudogene 1 Neighboring gene ADP ribosylation factor like GTPase 13A Neighboring gene tRNA methyltransferase 2 homolog B Neighboring gene transmembrane protein 35A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ60646

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
XK-related protein 2
Names
X Kell blood group precursor-related, X-linked
X-linked Kx blood group related, X-linked
XK, Kell blood group complex subunit-related, X-linked
membrane protein XPLAC

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021224.1 RefSeqGene

    Range
    4993..20465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_212559.3NP_997724.2  XK-related protein 2

    See identical proteins and their annotated locations for NP_997724.2

    Status: REVIEWED

    Source sequence(s)
    AI087330, AY589511, Z73417
    Consensus CDS
    CCDS14476.2
    UniProtKB/Swiss-Prot
    Q6PP77
    Related
    ENSP00000362047.2, ENST00000372956.3
    Conserved Domains (1) summary
    pfam09815
    Location:36407
    XK-related; XK-related protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    100886919..100957401 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530954.3XP_011529256.1  XK-related protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011529256.1

    Conserved Domains (1) summary
    pfam09815
    Location:49369
    XK-related; XK-related protein
  2. XM_011530955.1XP_011529257.1  XK-related protein 2 isoform X2

    Conserved Domains (1) summary
    pfam09815
    Location:35291
    XK-related; XK-related protein
  3. XM_005262130.3XP_005262187.1  XK-related protein 2 isoform X3

    UniProtKB/Swiss-Prot
    Q6PP77
    Conserved Domains (1) summary
    pfam09815
    Location:1203
    XK-related; XK-related protein
  4. XM_017029517.1XP_016885006.1  XK-related protein 2 isoform X3

    UniProtKB/Swiss-Prot
    Q6PP77
    Conserved Domains (1) summary
    pfam09815
    Location:1203
    XK-related; XK-related protein
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