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CASC15 cancer susceptibility 15 [ Homo sapiens (human) ]

Gene ID: 401237, updated on 12-Sep-2021


Official Symbol
CASC15provided by HGNC
Official Full Name
cancer susceptibility 15provided by HGNC
Primary source
See related
Gene type
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CANT; LINC00340; lnc-SOX4-1
This gene produces a long non-coding RNA that may regulate cell proliferation. This RNA is upregulated in hepatocellular carcinoma, where it is thought to function as an oncogene. However, some splice variants of this gene may function as a tumor suppressor in neuroblastoma and other tumor types. Circular RNA variants were observed at this gene. [provided by RefSeq, Dec 2017]
Broad expression in ovary (RPKM 2.9), endometrium (RPKM 1.9) and 14 other tissues See more
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Genomic context

See CASC15 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (21666413..22195820)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (21666644..22196049)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene bolA family member 2 pseudogene 3 Neighboring gene SRY-box transcription factor 4 Neighboring gene uncharacterized LOC105374970 Neighboring gene RN7SK pseudogene 240 Neighboring gene VISTA enhancer hs1335 Neighboring gene neuroblastoma associated transcript 1 Neighboring gene uncharacterized LOC105374971 Neighboring gene prolactin Neighboring gene HDGF like 1

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?


Associated conditions

Description Tests
Chromosome 6p22 locus associated with clinically aggressive neuroblastoma.
GeneReviews: Not available
Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma.
GeneReviews: Not available
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
GeneReviews: Not available
Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium.
GeneReviews: Not available
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
GeneReviews: Not available
Integrative genomics identifies LMO1 as a neuroblastoma oncogene.
GeneReviews: Not available

General gene information


Other Names

  • cancer susceptibility 15 (non-protein coding)
  • cancer susceptibility candidate 15 (non-protein coding)
  • long intergenic non-protein coding RNA 340

Clone Names

  • FLJ12803, FLJ17254, FLJ22536, FLJ51318

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.


  1. NR_015410.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AK026189, AL161436, AL359694, HY067675

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)
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