U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

IL17REL interleukin 17 receptor E like [ Homo sapiens (human) ]

Gene ID: 400935, updated on 4-Nov-2022

Summary

Official Symbol
IL17RELprovided by HGNC
Official Full Name
interleukin 17 receptor E likeprovided by HGNC
Primary source
HGNC:HGNC:33808
See related
Ensembl:ENSG00000188263 MIM:613414; AllianceGenome:HGNC:33808
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable interleukin-17 receptor activity. Predicted to be involved in cytokine-mediated signaling pathway. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See IL17REL in Genome Data Viewer
Location:
22q13.33
Exon count:
17
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (49991811..50012765, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (50496494..50517673, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (50430240..50451194, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene cysteine rich with EGF like domains 2 Neighboring gene microRNA 6821 Neighboring gene Pim-3 proto-oncogene, serine/threonine kinase Neighboring gene tubulin tyrosine ligase like 8 Neighboring gene modulator of VRAC current 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).
EBI GWAS Catalog
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ41993

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables interleukin-17 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
putative interleukin-17 receptor E-like
Names
IL-17 receptor E-like
IL-17RE-like

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001694.3NP_001001694.2  putative interleukin-17 receptor E-like isoform 1

    See identical proteins and their annotated locations for NP_001001694.2

    Status: VALIDATED

    Source sequence(s)
    AK123987, AL022327
    UniProtKB/Swiss-Prot
    A6PVC1, Q6ZVW7
    Conserved Domains (1) summary
    pfam15037
    Location:54294
    IL17_R_N; Interleukin-17 receptor extracellular region
  2. NM_001371416.1NP_001358345.1  putative interleukin-17 receptor E-like isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL022327
    Consensus CDS
    CCDS93181.1
    UniProtKB/TrEMBL
    A0A8Q3WLX3
    Related
    ENSP00000512283.1, ENST00000695951.1
    Conserved Domains (1) summary
    pfam15037
    Location:111366
    IL17_R_N; Interleukin-17 receptor extracellular region
  3. NM_001371417.1NP_001358346.1  putative interleukin-17 receptor E-like isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL022327
    Consensus CDS
    CCDS93182.1
    UniProtKB/TrEMBL
    A0A8Q3WKV1
    Related
    ENSP00000512282.1, ENST00000695950.1
    Conserved Domains (1) summary
    pfam15037
    Location:111461
    IL17_R_N; Interleukin-17 receptor extracellular region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    49991811..50012765 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001755245.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    50496494..50517673 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)