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PRICKLE3 prickle planar cell polarity protein 3 [ Homo sapiens (human) ]

Gene ID: 4007, updated on 1-Jun-2020

Summary

Official Symbol
PRICKLE3provided by HGNC
Official Full Name
prickle planar cell polarity protein 3provided by HGNC
Primary source
HGNC:HGNC:6645
See related
Ensembl:ENSG00000012211 MIM:300111
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Pk3; LMO6
Summary
LIM domain only 6 is a three LIM domain-containing protein. The LIM domain is a cysteine-rich sequence motif that binds zinc atoms to form a specific protein-binding interface for protein-protein interactions. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in skin (RPKM 16.7), esophagus (RPKM 11.7) and 24 other tissues See more
Orthologs

Genomic context

See PRICKLE3 in Genome Data Viewer
Location:
Xp11.23
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (49174802..49186373, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (49031546..49042981, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ZFP161 motif-containing MPRA enhancer 76/77 Neighboring gene MAGI family member, X-linked Neighboring gene proteolipid protein 2 Neighboring gene synaptophysin Neighboring gene SYP antisense RNA 1 Neighboring gene calcium voltage-gated channel subunit alpha1 F

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
cell projection organization IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
prickle planar cell polarity protein 3
Names
LIM domain only protein 6
LMO-6
prickle homolog 3
prickle-like protein 3
triple LIM domain protein 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017135.1 RefSeqGene

    Range
    4951..16626
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001307979.2NP_001294908.1  prickle planar cell polarity protein 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate 5' exon, contains an alternate 5' terminal exon, and uses a downstream start codon, compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA524273, AK299407, AK303200, BM981706, DC407811
    Consensus CDS
    CCDS78481.1
    UniProtKB/TrEMBL
    B7Z5U0, B7Z8D2, H0Y413
    Related
    ENSP00000388599.2, ENST00000453382.5
    Conserved Domains (4) summary
    cd09415
    Location:118176
    LIM1_Prickle; The first LIM domain of Prickle
    cd09418
    Location:181236
    LIM2_Prickle; The second LIM domain of Prickle
    cd09420
    Location:241299
    LIM3_Prickle; The third LIM domain of Prickle
    cd09827
    Location:14110
    PET_Prickle; The PET domain of Prickle
  2. NM_006150.5NP_006141.2  prickle planar cell polarity protein 3 isoform 1

    See identical proteins and their annotated locations for NP_006141.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA524273, AK299407, AK303200, BC002468, BC016856, BM981706, BP227957
    Consensus CDS
    CCDS14320.1
    UniProtKB/Swiss-Prot
    O43900
    UniProtKB/TrEMBL
    A0A024QYW5, B7Z5U0, B7Z8D2
    Related
    ENSP00000470248.1, ENST00000599218.6
    Conserved Domains (4) summary
    cd09415
    Location:186244
    LIM1_Prickle; The first LIM domain of Prickle
    cd09418
    Location:249304
    LIM2_Prickle; The second LIM domain of Prickle
    cd09420
    Location:309367
    LIM3_Prickle; The third LIM domain of Prickle
    cd09827
    Location:82178
    PET_Prickle; The PET domain of Prickle

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    49174802..49186373 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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