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LMO2 LIM domain only 2 [ Homo sapiens (human) ]

Gene ID: 4005, updated on 7-Dec-2018

Summary

Official Symbol
LMO2provided by HGNC
Official Full Name
LIM domain only 2provided by HGNC
Primary source
HGNC:HGNC:6642
See related
Ensembl:ENSG00000135363 MIM:180385
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TTG2; LMO-2; RBTN2; RHOM2; RBTNL1
Summary
LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2008]
Expression
Broad expression in bone marrow (RPKM 14.3), lymph node (RPKM 11.4) and 24 other tissues See more
Orthologs

Genomic context

See LMO2 in Genome Data Viewer
Location:
11p13
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (33858576..33892289, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (33880122..33913836, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376619 Neighboring gene uncharacterized LOC105376620 Neighboring gene uncharacterized LOC105376621 Neighboring gene VISTA enhancer hs1858

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
E-box binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II activating transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
bHLH transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
cofactor binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm TAS
Traceable Author Statement
more info
 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
rhombotin-2
Names
LIM domain only protein 2
T-cell translocation gene 2
T-cell translocation protein 2
cysteine-rich protein TTG-2
rhombotin-like 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142315.1NP_001135787.1  rhombotin-2 isoform 2

    See identical proteins and their annotated locations for NP_001135787.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream in-frame ATG and an isoform (2) with a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AC113192, BM690599, BM699014, X61118
    Consensus CDS
    CCDS44567.1
    UniProtKB/Swiss-Prot
    P25791
    Conserved Domains (2) summary
    cd09384
    Location:3085
    LIM1_LMO2; The first LIM domain of LMO2 (LIM domain only protein 2)
    cd09385
    Location:94149
    LIM2_LMO2; The second LIM domain of LMO2 (LIM domain only protein 2)
  2. NM_001142316.1NP_001135788.1  rhombotin-2 isoform 2

    See identical proteins and their annotated locations for NP_001135788.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has an additional segment downstream of the 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream in-frame ATG and an isoform (2) with a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AC113192, AC132216, BC035607, X61118
    Consensus CDS
    CCDS44567.1
    UniProtKB/Swiss-Prot
    P25791
    Related
    ENSP00000379175.3, ENST00000395833.7
    Conserved Domains (2) summary
    cd09384
    Location:3085
    LIM1_LMO2; The first LIM domain of LMO2 (LIM domain only protein 2)
    cd09385
    Location:94149
    LIM2_LMO2; The second LIM domain of LMO2 (LIM domain only protein 2)
  3. NM_005574.4NP_005565.2  rhombotin-2 isoform 1

    See identical proteins and their annotated locations for NP_005565.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform.
    Source sequence(s)
    AC113192, AC132216, CN355348, X61118
    Consensus CDS
    CCDS7888.2
    UniProtKB/Swiss-Prot
    P25791
    Related
    ENSP00000257818.2, ENST00000257818.2
    Conserved Domains (2) summary
    cd09384
    Location:99154
    LIM1_LMO2; The first LIM domain of LMO2 (LIM domain only protein 2)
    cd09385
    Location:163218
    LIM2_LMO2; The second LIM domain of LMO2 (LIM domain only protein 2)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    33858576..33892289 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017728.1XP_016873217.1  rhombotin-2 isoform X1

    UniProtKB/Swiss-Prot
    P25791
    Conserved Domains (2) summary
    cd09384
    Location:3085
    LIM1_LMO2; The first LIM domain of LMO2 (LIM domain only protein 2)
    cd09385
    Location:94149
    LIM2_LMO2; The second LIM domain of LMO2 (LIM domain only protein 2)
  2. XM_017017729.1XP_016873218.1  rhombotin-2 isoform X1

    UniProtKB/Swiss-Prot
    P25791
    Conserved Domains (2) summary
    cd09384
    Location:3085
    LIM1_LMO2; The first LIM domain of LMO2 (LIM domain only protein 2)
    cd09385
    Location:94149
    LIM2_LMO2; The second LIM domain of LMO2 (LIM domain only protein 2)
  3. XM_017017733.1XP_016873222.1  rhombotin-2 isoform X1

    UniProtKB/Swiss-Prot
    P25791
    Conserved Domains (2) summary
    cd09384
    Location:3085
    LIM1_LMO2; The first LIM domain of LMO2 (LIM domain only protein 2)
    cd09385
    Location:94149
    LIM2_LMO2; The second LIM domain of LMO2 (LIM domain only protein 2)
  4. XM_017017732.1XP_016873221.1  rhombotin-2 isoform X1

    UniProtKB/Swiss-Prot
    P25791
    Conserved Domains (2) summary
    cd09384
    Location:3085
    LIM1_LMO2; The first LIM domain of LMO2 (LIM domain only protein 2)
    cd09385
    Location:94149
    LIM2_LMO2; The second LIM domain of LMO2 (LIM domain only protein 2)
  5. XM_017017731.1XP_016873220.1  rhombotin-2 isoform X1

    UniProtKB/Swiss-Prot
    P25791
    Conserved Domains (2) summary
    cd09384
    Location:3085
    LIM1_LMO2; The first LIM domain of LMO2 (LIM domain only protein 2)
    cd09385
    Location:94149
    LIM2_LMO2; The second LIM domain of LMO2 (LIM domain only protein 2)
  6. XM_017017730.1XP_016873219.1  rhombotin-2 isoform X1

    UniProtKB/Swiss-Prot
    P25791
    Conserved Domains (2) summary
    cd09384
    Location:3085
    LIM1_LMO2; The first LIM domain of LMO2 (LIM domain only protein 2)
    cd09385
    Location:94149
    LIM2_LMO2; The second LIM domain of LMO2 (LIM domain only protein 2)
  7. XM_017017727.2XP_016873216.1  rhombotin-2 isoform X1

    UniProtKB/Swiss-Prot
    P25791
    Conserved Domains (2) summary
    cd09384
    Location:3085
    LIM1_LMO2; The first LIM domain of LMO2 (LIM domain only protein 2)
    cd09385
    Location:94149
    LIM2_LMO2; The second LIM domain of LMO2 (LIM domain only protein 2)
  8. XM_005252921.3XP_005252978.1  rhombotin-2 isoform X1

    See identical proteins and their annotated locations for XP_005252978.1

    UniProtKB/Swiss-Prot
    P25791
    Conserved Domains (2) summary
    cd09384
    Location:3085
    LIM1_LMO2; The first LIM domain of LMO2 (LIM domain only protein 2)
    cd09385
    Location:94149
    LIM2_LMO2; The second LIM domain of LMO2 (LIM domain only protein 2)
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