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FAM174B family with sequence similarity 174 member B [ Homo sapiens (human) ]

Gene ID: 400451, updated on 22-Sep-2022

Summary

Official Symbol
FAM174Bprovided by HGNC
Official Full Name
family with sequence similarity 174 member Bprovided by HGNC
Primary source
HGNC:HGNC:34339
See related
Ensembl:ENSG00000185442 AllianceGenome:HGNC:34339
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Involved in Golgi organization. Located in Golgi apparatus and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in prostate (RPKM 17.8), thyroid (RPKM 16.6) and 25 other tissues See more
Orthologs
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Genomic context

See FAM174B in Genome Data Viewer
Location:
15q26.1
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (92617448..92655775, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (90379890..90418117, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (93160678..93199005, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene chromosome 15 putative open reading frame 32 Neighboring gene long intergenic non-protein coding RNA 930 Neighboring gene uncharacterized LOC124903559 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 38 Neighboring gene ribosomal protein L31 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population.
EBI GWAS Catalog

General gene information

Markers

Homology

Clone Names

  • MGC102891

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in Golgi organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207446.3NP_997329.2  membrane protein FAM174B precursor

    See identical proteins and their annotated locations for NP_997329.2

    Status: VALIDATED

    Source sequence(s)
    AC091544, BC060873
    Consensus CDS
    CCDS45355.1
    UniProtKB/Swiss-Prot
    Q3ZCQ3, Q8NBH7
    Related
    ENSP00000329040.5, ENST00000327355.6
    Conserved Domains (1) summary
    pfam06679
    Location:75158
    DUF1180; Protein of unknown function (DUF1180)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    92617448..92655775 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    90379890..90418117 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)