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TMEM200B transmembrane protein 200B [ Homo sapiens (human) ]

Gene ID: 399474, updated on 11-Jun-2021

Summary

Official Symbol
TMEM200Bprovided by HGNC
Official Full Name
transmembrane protein 200Bprovided by HGNC
Primary source
HGNC:HGNC:33785
See related
Ensembl:ENSG00000253304
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TTMB
Expression
Ubiquitous expression in endometrium (RPKM 25.9), prostate (RPKM 14.5) and 25 other tissues See more
Orthologs
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Genomic context

See TMEM200B in Genome Data Viewer
Location:
1p35.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (29119429..29129138, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (29445941..29450415, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr1.4082 Neighboring gene erythrocyte membrane protein band 4.1 Neighboring gene ribosomal protein L27 pseudogene 4 Neighboring gene serine and arginine rich splicing factor 4 Neighboring gene mitochondrial trans-2-enoyl-CoA reductase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC90489, MGC102864

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein 200B
Names
transmembrane protein TTMA
two transmembrane B
two transmembrane domain-containing family member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003682.4NP_001003682.1  transmembrane protein 200B

    See identical proteins and their annotated locations for NP_001003682.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI367819, BC064375, BC082989, BC110336
    Consensus CDS
    CCDS30658.1
    UniProtKB/Swiss-Prot
    Q69YZ2
    Related
    ENSP00000428459.1, ENST00000521452.2
    Conserved Domains (1) summary
    pfam10177
    Location:50147
    DUF2371; Uncharacterized conserved protein (DUF2371)
  2. NM_001171868.2NP_001165339.1  transmembrane protein 200B

    See identical proteins and their annotated locations for NP_001165339.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI367819, BC110336
    Consensus CDS
    CCDS30658.1
    UniProtKB/Swiss-Prot
    Q69YZ2
    Related
    ENSP00000428544.1, ENST00000420504.2
    Conserved Domains (1) summary
    pfam10177
    Location:50147
    DUF2371; Uncharacterized conserved protein (DUF2371)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    29119429..29129138 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541457.2XP_011539759.1  transmembrane protein 200B isoform X1

    Conserved Domains (1) summary
    pfam10177
    Location:61158
    DUF2371; uncharacterized conserved protein (DUF2371)
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