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LIPE lipase E, hormone sensitive type [ Homo sapiens (human) ]

Gene ID: 3991, updated on 26-Nov-2021

Summary

Official Symbol
LIPEprovided by HGNC
Official Full Name
lipase E, hormone sensitive typeprovided by HGNC
Primary source
HGNC:HGNC:6621
See related
Ensembl:ENSG00000079435 MIM:151750
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSL; LHS; REH; AOMS4; FPLD6
Summary
The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008]
Expression
Biased expression in fat (RPKM 187.4) and testis (RPKM 12.7) See more
Orthologs
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Genomic context

See LIPE in Genome Data Viewer
Location:
19q13.2
Exon count:
15
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (42401512..42427421, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42905666..42931540, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene multiple EGF like domains 8 Neighboring gene microRNA 8077 Neighboring gene uncharacterized LOC101930071 Neighboring gene LIPE antisense RNA 1 Neighboring gene cornifelin Neighboring gene C-X-C motif chemokine ligand 17 Neighboring gene RNA, U4 small nuclear 60, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 1,2-diacylglycerol acylhydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables 1,3-diacylglycerol acylhydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables acylglycerol lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity IEA
Inferred from Electronic Annotation
more info
 
enables hormone-sensitive lipase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables retinyl-palmitate esterase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sterol esterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sterol esterase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables triglyceride lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables triglyceride lipase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in diacylglycerol catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ether lipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in lipid catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in retinol metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in triglyceride catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in triglyceride catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in caveola IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in lipid droplet ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
hormone-sensitive lipase
Names
lipase, hormone-sensitive
monoacylglycerol lipase LIPE
retinyl ester hydrolase
NP_005348.2
XP_005258994.1
XP_005258995.1
XP_005258996.2
XP_005258997.1
XP_006723281.1
XP_016882299.1
XP_024307282.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034246.1 RefSeqGene

    Range
    5039..30913
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005357.4NP_005348.2  hormone-sensitive lipase

    See identical proteins and their annotated locations for NP_005348.2

    Status: REVIEWED

    Source sequence(s)
    AK292482, BC070041
    Consensus CDS
    CCDS12607.1
    UniProtKB/Swiss-Prot
    Q05469
    UniProtKB/TrEMBL
    A8K8W7
    Related
    ENSP00000244289.3, ENST00000244289.9
    Conserved Domains (4) summary
    COG0657
    Location:637790
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam06350
    Location:307615
    HSL_N; Hormone-sensitive lipase (HSL) N-terminus
    pfam16228
    Location:30134
    DUF4887; Domain of unknown function (DUF4887)
    cl21494
    Location:647795
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    42401512..42427421 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258937.3XP_005258994.1  hormone-sensitive lipase isoform X1

    Conserved Domains (4) summary
    COG0657
    Location:637975
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam06350
    Location:307615
    HSL_N; Hormone-sensitive lipase (HSL) N-terminus
    pfam16228
    Location:30134
    DUF4887; Domain of unknown function (DUF4887)
    cl21494
    Location:647952
    Abhydrolase; alpha/beta hydrolases
  2. XM_005258938.5XP_005258995.1  hormone-sensitive lipase isoform X3

    Conserved Domains (3) summary
    COG0657
    Location:382535
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam06350
    Location:52360
    HSL_N; Hormone-sensitive lipase (HSL) N-terminus
    cl21494
    Location:392540
    Abhydrolase; alpha/beta hydrolases
  3. XM_024451514.1XP_024307282.1  hormone-sensitive lipase isoform X5

    Conserved Domains (2) summary
    pfam06350
    Location:52360
    HSL_N; Hormone-sensitive lipase (HSL) N-terminus
    cl21494
    Location:392697
    Abhydrolase; alpha/beta hydrolases
  4. XM_006723218.3XP_006723281.1  hormone-sensitive lipase isoform X4

    See identical proteins and their annotated locations for XP_006723281.1

    UniProtKB/Swiss-Prot
    Q05469
    Conserved Domains (3) summary
    COG0657
    Location:336489
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam06350
    Location:6314
    HSL_N; Hormone-sensitive lipase (HSL) N-terminus
    cl21494
    Location:346494
    Abhydrolase; alpha/beta hydrolases
  5. XM_005258939.3XP_005258996.2  hormone-sensitive lipase isoform X2

    Conserved Domains (3) summary
    COG0657
    Location:399552
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam06350
    Location:69377
    HSL_N; Hormone-sensitive lipase (HSL) N-terminus
    cl21494
    Location:409557
    Abhydrolase; alpha/beta hydrolases
  6. XM_005258940.3XP_005258997.1  hormone-sensitive lipase isoform X4

    See identical proteins and their annotated locations for XP_005258997.1

    UniProtKB/Swiss-Prot
    Q05469
    Conserved Domains (3) summary
    COG0657
    Location:336489
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam06350
    Location:6314
    HSL_N; Hormone-sensitive lipase (HSL) N-terminus
    cl21494
    Location:346494
    Abhydrolase; alpha/beta hydrolases
  7. XM_017026810.1XP_016882299.1  hormone-sensitive lipase isoform X4

    UniProtKB/Swiss-Prot
    Q05469
    Conserved Domains (3) summary
    COG0657
    Location:336489
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam06350
    Location:6314
    HSL_N; Hormone-sensitive lipase (HSL) N-terminus
    cl21494
    Location:346494
    Abhydrolase; alpha/beta hydrolases
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