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IntS9 Integrator 9 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39763, updated on 18-Sep-2024

Summary

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Official Symbol
IntS9provided by FlyBase
Official Full Name
Integrator 9provided by FlyBase
Primary source
FLYBASE:FBgn0036570
Locus tag
Dmel_CG5222
See related
AllianceGenome:FB:FBgn0036570
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5222; Dmel\CG5222; Int9; Ints9
Summary
Involved in snRNA 3'-end processing. Predicted to be located in nucleus. Predicted to be part of integrator complex. Orthologous to human INTS9 (integrator complex subunit 9). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
72D6-72D6; 3-44 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16103432..16105627, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16096532..16098727, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Chloride channel-c Neighboring gene uncharacterized protein Neighboring gene ATP synthase, beta subunit-like Neighboring gene Isoleucyl-tRNA synthetase, mitochondrial Neighboring gene uncharacterized protein Neighboring gene Zinc-finger protein at 72D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Integrator Complex Attenuates Promoter-Proximal Transcription at Protein-Coding Genes. Elrod ND, et al. Mol Cell, 2019 Dec 5. PMID 31809743, Free PMC Article
  2. Antisense oligonucleotide technology can be used to investigate a circular but not linear RNA-mediated function for its encoded gene locus. Song Z, et al. Sci China Life Sci, 2021 May. PMID 32815066
  3. Functional analysis of the integrator subunit 12 identifies a microdomain that mediates activation of the Drosophila integrator complex. Chen J, et al. J Biol Chem, 2013 Feb 15. PMID 23288851, Free PMC Article
  4. Attenuation of Eukaryotic Protein-Coding Gene Expression via Premature Transcription Termination. Tatomer DC, et al. Cold Spring Harb Symp Quant Biol, 2019. PMID 32086332
  5. The Integrator complex desensitizes cellular response to TGF-β/BMP signaling. Liu S, et al. Cell Rep, 2023 Jan 31. PMID 36641752

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in negative regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snRNA 3'-end processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in snRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in snRNA processing ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrator complex IEA
Inferred from Electronic Annotation
more info
  
part_of integrator complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
integrator 9
Names
CG5222-PA
IntS9-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    16103432..16105627 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140581.4 → NP_648838.3  integrator 9 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648838.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95TS5, Q9VUY5
    Related
    FBpp0075250
    Conserved Domains (2) summary
    smart01027
    Location:304 → 428
    Beta-Casp; Beta-Casp domain
    cl23716
    Location:1 → 264
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95TS5.1 Q95TS5

Gene LinkOut

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