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ADAM17 ADAM metallopeptidase domain 17 [ Sus scrofa (pig) ]

Gene ID: 397343, updated on 17-Aug-2024

Summary

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Official Symbol
ADAM17provided by VGNC
Official Full Name
ADAM metallopeptidase domain 17provided by VGNC
Primary source
VGNC:VGNC:85065
See related
Ensembl:ENSSSCG00000008641
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
TACE
Expression
Ubiquitous expression in lung (RPKM 15.9), spleen (RPKM 14.8) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 3
Exon count:
20
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 3 NC_010445.4 (126795513..126853995)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 3 NC_010445.3 (135176533..135222632, complement)

Chromosome 3 - NC_010445.4Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor, RNA polymerase I subunit B Neighboring gene uncharacterized LOC102158714 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta Neighboring gene isoamyl acetate hydrolyzing esterase 1 (putative) Neighboring gene cleavage and polyadenylation specific factor 3 Neighboring gene integrin subunit beta 1 binding protein 1 Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Protein kinase C (PKC) increases TACE/ADAM17 enzyme activity in porcine ovarian somatic cells, which is essential for granulosa cell luteinization and oocyte maturation. Yamashita Y, et al. Endocrinology, 2014 Mar. PMID 24424050
  2. Production of porcine TNFα by ADAM17-mediated cleavage negatively regulates porcine reproductive and respiratory syndrome virus infection. Li R, et al. Immunol Res, 2016 Jun. PMID 26724939
  3. Elevated plasma-soluble CD16 levels in porcine reproductive and respiratory syndrome virus-infected pigs: correlation with ADAM17-mediated shedding. Gu W, et al. J Gen Virol, 2016 Mar. PMID 26653711
  4. Modulation of CD163 expression by metalloprotease ADAM17 regulates porcine reproductive and respiratory syndrome virus entry. Guo L, et al. J Virol, 2014 Sep. PMID 24965453, Free PMC Article
  5. Progesterone is essential for maintenance of Tace/Adam17 mRNA expression, but not EGF-like factor, in cumulus cells, which enhances the EGF receptor signaling pathway during in vitro maturation of porcine COCs. Yamashita Y, et al. J Reprod Dev, 2010 Jun. PMID 20168049

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these findings provide the direct evidence that ADAM17 cleaves porcine TNFalpha, which represents a new view for identifying potential therapeutic targets in anti-porcine reproductive and respiratory syndrome virus therapy
    Title: Production of porcine TNFα by ADAM17-mediated cleavage negatively regulates porcine reproductive and respiratory syndrome virus infection.
  2. ADAM17 was involved in porcine CD16 shedding in porcine reproductive and respiratory syndrome virus-infected pigs.
    Title: Elevated plasma-soluble CD16 levels in porcine reproductive and respiratory syndrome virus-infected pigs: correlation with ADAM17-mediated shedding.
  3. Overexpression of ADAM17 induced downregulation of CD163 expression and a reduction in reproductive and respiratory syndrome virus infection.
    Title: Modulation of CD163 expression by metalloprotease ADAM17 regulates porcine reproductive and respiratory syndrome virus entry.
  4. activation of TACE/ADAM17 via a PKC-induced c-Src-dependent manner mediates proteolytic activation of the EGF-like factors that are involved in the induction of granulosa cell differentiation, cumulus expansion, and meiotic maturation of porcine oocytes
    Title: Protein kinase C (PKC) increases TACE/ADAM17 enzyme activity in porcine ovarian somatic cells, which is essential for granulosa cell luteinization and oocyte maturation.
  5. Data indicate that TNF-alpha stimulates Rac, ADAM17/TACE, and RhoA through the guanine nucleotide exchange factor (GEF)-H1.
    Title: Central role of the exchange factor GEF-H1 in TNF-α-induced sequential activation of Rac, ADAM17/TACE, and RhoA in tubular epithelial cells.
  6. progesterone-induced TACE/ADAM17 leads to production of soluble EGF domain from cumulus cells, which enhances functional changes of cumulus cells and progresses meiotic maturation of oocytes
    Title: Progesterone is essential for maintenance of Tace/Adam17 mRNA expression, but not EGF-like factor, in cumulus cells, which enhances the EGF receptor signaling pathway during in vitro maturation of porcine COCs.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
disintegrin and metalloproteinase domain-containing protein 17
Names
ADAM 17
TNF-alpha convertase
TNF-alpha converting enzyme
a disintegrin and metallopeptidase domain 17
NP_001093396.1
XP_020941512.1
XP_020941513.1
XP_020941514.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099926.1 → NP_001093396.1  disintegrin and metalloproteinase domain-containing protein 17 precursor

    See identical proteins and their annotated locations for NP_001093396.1

    Status: PROVISIONAL

    Source sequence(s)
    AB271919
    UniProtKB/Swiss-Prot
    A5A749, O77636
    UniProtKB/TrEMBL
    A0A8D0LFA7, A0A8D0Q890
    Related
    ENSSSCP00000065601.1, ENSSSCT00000072504.2
    Conserved Domains (5) summary
    smart00050
    Location:484 → 560
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:223 → 477
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam01562
    Location:56 → 162
    Pep_M12B_propep; Reprolysin family propeptide
    pfam13574
    Location:247 → 460
    Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like
    pfam16698
    Location:581 → 641
    ADAM17_MPD; Membrane-proximal domain, switch, for ADAM17

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010445.4 Reference Sscrofa11.1 Primary Assembly

    Range
    126795513..126853995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021085854.1 → XP_020941513.1  disintegrin and metalloproteinase domain-containing protein 17 isoform X1

    Conserved Domains (3) summary
    smart00050
    Location:246 → 322
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:1 → 239
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam16698
    Location:343 → 403
    ADAM17_MPD; Membrane-proximal domain, switch, for ADAM17

  2. XM_021085853.1 → XP_020941512.1  disintegrin and metalloproteinase domain-containing protein 17 isoform X1

    Conserved Domains (3) summary
    smart00050
    Location:246 → 322
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:1 → 239
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam16698
    Location:343 → 403
    ADAM17_MPD; Membrane-proximal domain, switch, for ADAM17

  3. XM_021085855.1 → XP_020941514.1  disintegrin and metalloproteinase domain-containing protein 17 isoform X1

    Conserved Domains (3) summary
    smart00050
    Location:246 → 322
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:1 → 239
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam16698
    Location:343 → 403
    ADAM17_MPD; Membrane-proximal domain, switch, for ADAM17
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O77636.2 GenPept UniProtKB/Swiss-Prot:O77636

Gene LinkOut

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