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LHB luteinizing hormone subunit beta [ Homo sapiens (human) ]

Gene ID: 3972, updated on 7-Jun-2020

Summary

Official Symbol
LHBprovided by HGNC
Official Full Name
luteinizing hormone subunit betaprovided by HGNC
Primary source
HGNC:HGNC:6584
See related
Ensembl:ENSG00000104826 MIM:152780
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGB4; HH23; LSH-B; LSH-beta
Summary
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. [provided by RefSeq, Jul 2008]
Expression
Biased expression in pancreas (RPKM 1.7), testis (RPKM 1.1) and 7 other tissues See more
Orthologs

Genomic context

See LHB in Genome Data Viewer
Location:
19q13.33
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (49015980..49017091, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49519237..49520350, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RuvB like AAA ATPase 2 Neighboring gene Sharpr-MPRA regulatory region 732 Neighboring gene microRNA 6798 Neighboring gene uncharacterized LOC101059948 Neighboring gene chorionic gonadotropin subunit beta 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
hormone-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
male gonad development TAS
Traceable Author Statement
more info
PubMed 
peptide hormone processing TAS
Traceable Author Statement
more info
 
progesterone biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi lumen TAS
Traceable Author Statement
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
lutropin subunit beta
Names
interstitial cell stimulating hormone, beta chain
luteinizing hormone beta polypeptide
luteinizing hormone beta subunit
lutropin beta chain

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011464.1 RefSeqGene

    Range
    5001..6111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000894.3NP_000885.1  lutropin subunit beta precursor

    See identical proteins and their annotated locations for NP_000885.1

    Status: REVIEWED

    Source sequence(s)
    AC008687
    Consensus CDS
    CCDS12748.1
    UniProtKB/Swiss-Prot
    P01229
    UniProtKB/TrEMBL
    A0A0F7RQE6
    Related
    ENSP00000497294.1, ENST00000649238.2
    Conserved Domains (1) summary
    smart00068
    Location:25131
    GHB; Glycoprotein hormone beta chain homologues

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    49015980..49017091 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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