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SMAD1 SMAD family member 1 [ Sus scrofa (pig) ]

Gene ID: 397016, updated on 17-Aug-2024

Summary

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Official Symbol
SMAD1provided by VGNC
Official Full Name
SMAD family member 1provided by VGNC
Primary source
VGNC:VGNC:93216
See related
Ensembl:ENSSSCG00000009040
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
MADH1
Expression
Ubiquitous expression in ovary (RPKM 5.3), lung (RPKM 5.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 8
Exon count:
11
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 8 NC_010450.4 (82907557..82987909, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) Unplaced Scaffold NW_003537317.1 (12958..31371, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) Unplaced Scaffold NW_003537833.1 (4349..5005)

Chromosome 8 - NC_010450.4Genomic Context describing neighboring genes Neighboring gene LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene zinc finger protein 827 Neighboring gene methylmalonic aciduria type A protein, mitochondrial Neighboring gene uncharacterized LOC102165892 Neighboring gene uncharacterized LOC110262147 Neighboring gene 40S ribosomal protein S23 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Linkage mapping of a SNP in the porcine MADH1 gene to a region of chromosome 8 that contains QTL for uterine capacity. Kim JG, et al. Anim Genet, 2003 Aug. PMID 12873226
  2. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article
  3. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables I-SMAD binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in SMAD protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of heteromeric SMAD protein complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mothers against decapentaplegic homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213965.1 → NP_999130.1  mothers against decapentaplegic homolog 1

    See identical proteins and their annotated locations for NP_999130.1

    Status: PROVISIONAL

    Source sequence(s)
    AY245888
    UniProtKB/TrEMBL
    A0A4X1VDX3, A0A8D0JBS0, F6Q023, Q864V7
    Conserved Domains (3) summary
    cd10490
    Location:9 → 132
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265 → 465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
    cl28087
    Location:133 → 251
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010450.4 Reference Sscrofa11.1 Primary Assembly

    Range
    82907557..82987909 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021100455.1 → XP_020956114.1  mothers against decapentaplegic homolog 1 isoform X1

    UniProtKB/TrEMBL
    A0A4X1VDX3, A0A8D0JBS0, F6Q023, Q864V7
    Conserved Domains (3) summary
    cd10490
    Location:9 → 132
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265 → 465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
    cl28087
    Location:133 → 251
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

  2. XM_021100454.1 → XP_020956113.1  mothers against decapentaplegic homolog 1 isoform X1

    UniProtKB/TrEMBL
    A0A4X1VDX3, A0A8D0JBS0, F6Q023, Q864V7
    Conserved Domains (3) summary
    cd10490
    Location:9 → 132
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265 → 465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
    cl28087
    Location:133 → 251
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

  3. XM_021100452.1 → XP_020956111.1  mothers against decapentaplegic homolog 1 isoform X1

    UniProtKB/TrEMBL
    A0A4X1VDX3, A0A8D0JBS0, F6Q023, Q864V7
    Conserved Domains (3) summary
    cd10490
    Location:9 → 132
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265 → 465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
    cl28087
    Location:133 → 251
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

  4. XM_021100451.1 → XP_020956110.1  mothers against decapentaplegic homolog 1 isoform X1

    UniProtKB/TrEMBL
    A0A4X1VDX3, A0A8D0JBS0, F6Q023, Q864V7
    Conserved Domains (3) summary
    cd10490
    Location:9 → 132
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265 → 465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
    cl28087
    Location:133 → 251
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

  5. XM_021100448.1 → XP_020956107.1  mothers against decapentaplegic homolog 1 isoform X1

    UniProtKB/TrEMBL
    A0A4X1VDX3, A0A8D0JBS0, F6Q023, Q864V7
    Conserved Domains (3) summary
    cd10490
    Location:9 → 132
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265 → 465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
    cl28087
    Location:133 → 251
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

  6. XM_021100449.1 → XP_020956108.1  mothers against decapentaplegic homolog 1 isoform X1

    UniProtKB/TrEMBL
    A0A4X1VDX3, A0A8D0JBS0, F6Q023, Q864V7
    Conserved Domains (3) summary
    cd10490
    Location:9 → 132
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265 → 465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
    cl28087
    Location:133 → 251
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

  7. XM_021100453.1 → XP_020956112.1  mothers against decapentaplegic homolog 1 isoform X1

    UniProtKB/TrEMBL
    A0A4X1VDX3, A0A8D0JBS0, F6Q023, Q864V7
    Related
    ENSSSCP00000032660.1, ENSSSCT00000062941.2
    Conserved Domains (3) summary
    cd10490
    Location:9 → 132
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265 → 465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
    cl28087
    Location:133 → 251
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
Nucleotide Protein
Heading Accession and Version

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