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LECT2 leukocyte cell derived chemotaxin 2 [ Homo sapiens (human) ]

Gene ID: 3950, updated on 23-Nov-2021

Summary

Official Symbol
LECT2provided by HGNC
Official Full Name
leukocyte cell derived chemotaxin 2provided by HGNC
Primary source
HGNC:HGNC:6550
See related
Ensembl:ENSG00000145826 MIM:602882
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
chm2; chm-II
Summary
This gene encodes a secreted, 16 kDa protein that acts as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. This protein has high sequence similarity to the chondromodulin repeat regions of the chicken myb-induced myeloid 1 protein. A polymorphism in this gene may be associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward liver (RPKM 110.6) See more
Orthologs
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Genomic context

See LECT2 in Genome Data Viewer
Location:
5q31.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (135946904..135954983, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (135282593..135290672, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene interleukin 9 Neighboring gene F-box and leucine rich repeat protein 21, pseudogene Neighboring gene Sharpr-MPRA regulatory region 2274 Neighboring gene uncharacterized LOC105379189 Neighboring gene transforming growth factor beta induced

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126628

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in skeletal system development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in extracellular space TAS
Traceable Author Statement
more info
PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
leukocyte cell-derived chemotaxin-2
Names
chondromodulin-II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002302.3NP_002293.2  leukocyte cell-derived chemotaxin-2 precursor

    See identical proteins and their annotated locations for NP_002293.2

    Status: REVIEWED

    Source sequence(s)
    AC002428
    Consensus CDS
    CCDS4190.1
    UniProtKB/Swiss-Prot
    O14960
    Related
    ENSP00000274507.1, ENST00000274507.6
    Conserved Domains (1) summary
    pfam01551
    Location:51147
    Peptidase_M23; Peptidase family M23

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    135946904..135954983 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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