Smyd4-2 SET and MYND domain containing, class 4, member 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Smyd4-2provided by FlyBase
Official Full Name: SET and MYND domain containing, class 4, member 2provided by FlyBase
Primary source: FLYBASE:FBgn0036282
Locus tag: Dmel_CG14122
See related: AllianceGenome:FB:FBgn0036282
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG14122; Dmel\CG14122; dSmyd4; Smyd4
Summary: Enables histone deacetylase binding activity. Involved in compound eye photoreceptor development; eclosion; and negative regulation of gene expression. Located in cytoplasm and nucleus. Is expressed in embryonic/larval muscle system; extended germ band embryo; testis; and visceral muscle primordium. Orthologous to human SMYD4 (SET and MYND domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (12399539..12401935, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (12392639..12395035, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables histone H3K4 methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone deacetylase binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in compound eye photoreceptor development	IBA Inferred from Biological aspect of Ancestor more info
involved_in compound eye photoreceptor development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eclosion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

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