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Klp68D Kinesin-like protein at 68D [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39332, updated on 4-Apr-2024

Summary

Official Symbol
Klp68Dprovided by FlyBase
Official Full Name
Kinesin-like protein at 68Dprovided by FlyBase
Primary source
FLYBASE:FBgn0004381
Locus tag
Dmel_CG7293
See related
AllianceGenome:FB:FBgn0004381
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7293; Dmel\CG7293; DmKlp68D; KIF 3B; KIF3B; KLP-5; Klp5; KLP5; klp68d; KLP68D; KLP68Ddm; KLP[[64D/68D]]
Summary
Enables cytoskeletal motor activity. Involved in anterograde axonal transport; establishment or maintenance of microtubule cytoskeleton polarity; and sensory perception of smell. Part of microtubule associated complex. Is expressed in several structures, including gonad; indirect flight muscle cell; presumptive embryonic/larval system; sensory nervous system primordium; and ventral sensory complex primordium. Human ortholog(s) of this gene implicated in retinitis pigmentosa 89. Orthologous to human KIF3B (kinesin family member 3B) and KIF3C (kinesin family member 3C). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See Klp68D in Genome Data Viewer
Location:
68D6-68E1; 3-36 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11795614..11798875)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11788714..11791975)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene twitchy Neighboring gene uncharacterized protein Neighboring gene Glycine C-acetyltransferase Neighboring gene transfer RNA:Glutamine-TTG 1-1

Genomic regions, transcripts, and products

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cytoskeletal motor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cytoskeletal motor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in anterograde axonal transport IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in anterograde axonal transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment or maintenance of microtubule cytoskeleton polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule-based movement IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sensory perception of smell IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of microtubule associated complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Kinesin-like protein at 68D
Names
CG7293-PA
CG7293-PB
Kinesin-2
Kinesin1
Klp68D-PA
Klp68D-PB
kinesin II

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    11795614..11798875
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079305.3NP_524029.2  Kinesin-like protein at 68D, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524029.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P46867, Q961H5, Q9VTN8
    UniProtKB/TrEMBL
    M9PF68
    Related
    FBpp0075762
    Conserved Domains (4) summary
    smart00129
    Location:20351
    KISc; Kinesin motor, catalytic domain. ATPase
    cl22853
    Location:18344
    Motor_domain; Myosin and Kinesin motor domain
    cd16269
    Location:547558
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:479576
    GBP_C; Guanylate-binding protein, C-terminal domain
  2. NM_001274797.1NP_001261726.1  Kinesin-like protein at 68D, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261726.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P46867, Q961H5, Q9VTN8
    UniProtKB/TrEMBL
    M9PF68
    Conserved Domains (4) summary
    smart00129
    Location:20351
    KISc; Kinesin motor, catalytic domain. ATPase
    cl22853
    Location:18344
    Motor_domain; Myosin and Kinesin motor domain
    cd16269
    Location:547558
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:479576
    GBP_C; Guanylate-binding protein, C-terminal domain