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HES3 hes family bHLH transcription factor 3 [ Homo sapiens (human) ]

Gene ID: 390992, updated on 13-Mar-2020

Summary

Official Symbol
HES3provided by HGNC
Official Full Name
hes family bHLH transcription factor 3provided by HGNC
Primary source
HGNC:HGNC:26226
See related
Ensembl:ENSG00000173673 MIM:609971
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
bHLHb43
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See HES3 in Genome Data Viewer
Location:
1p36.31
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (6244179..6245578)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (6304252..6305638)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ring finger protein 207 Neighboring gene isoprenylcysteine carboxyl methyltransferase Neighboring gene long intergenic non-protein coding RNA 337 Neighboring gene G protein-coupled receptor 153 Neighboring gene acyl-CoA thioesterase 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
anterior/posterior pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hindbrain morphogenesis IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
midbrain development IEA
Inferred from Electronic Annotation
more info
 
midbrain-hindbrain boundary morphogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oculomotor nerve development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of timing of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
trochlear nerve development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transcription factor HES-3
Names
class B basic helix-loop-helix protein 43
hairy and enhancer of split 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024598.4NP_001019769.1  transcription factor HES-3

    See identical proteins and their annotated locations for NP_001019769.1

    Status: VALIDATED

    Source sequence(s)
    AL031847, CN370501
    Consensus CDS
    CCDS41238.1
    UniProtKB/Swiss-Prot
    Q5TGS1
    Related
    ENSP00000367130.3, ENST00000377898.4
    Conserved Domains (1) summary
    cd00083
    Location:154
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    6244179..6245578
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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