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LALBA lactalbumin alpha [ Homo sapiens (human) ]

Gene ID: 3906, updated on 26-Oct-2022

Summary

Official Symbol
LALBAprovided by HGNC
Official Full Name
lactalbumin alphaprovided by HGNC
Primary source
HGNC:HGNC:6480
See related
Ensembl:ENSG00000167531 MIM:149750; AllianceGenome:HGNC:6480
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LYZG; HAMLET
Summary
This gene encodes alpha-lactalbumin, a principal protein of milk. Alpha-lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta 1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transfering galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See LALBA in Genome Data Viewer
Location:
12q13.11
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (48567684..48571845, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (48529699..48533867, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (48961467..48965628, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 8 subfamily S member 1 Neighboring gene olfactory receptor family 5 subfamily BS member 1 pseudogene Neighboring gene olfactory receptor family 11 subfamily M member 1 pseudogene Neighboring gene uncharacterized LOC124902928

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138521, MGC138523

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables lactose synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables lysozyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic process TAS
Traceable Author Statement
more info
PubMed 
involved_in cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
involved_in defense response to bacterium TAS
Traceable Author Statement
more info
PubMed 
involved_in lactose biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi lumen TAS
Traceable Author Statement
more info
 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
located_in extracellular space TAS
Traceable Author Statement
more info
PubMed 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
alpha-lactalbumin
Names
lactose synthase B protein
lysozyme G
lysozyme-like protein 7
NP_001371279.1
NP_002280.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001384350.1NP_001371279.1  alpha-lactalbumin precursor

    Status: REVIEWED

    Source sequence(s)
    AC089987
    Consensus CDS
    CCDS8765.1
    UniProtKB/Swiss-Prot
    Q9UDK4
    UniProtKB/TrEMBL
    A0A080YV01
    Conserved Domains (1) summary
    pfam00062
    Location:20138
    Lys; C-type lysozyme/alpha-lactalbumin family
  2. NM_002289.3NP_002280.1  alpha-lactalbumin precursor

    See identical proteins and their annotated locations for NP_002280.1

    Status: REVIEWED

    Source sequence(s)
    AC089987
    Consensus CDS
    CCDS8765.1
    UniProtKB/Swiss-Prot
    P00709, Q9UDK4
    UniProtKB/TrEMBL
    A0A080YV01
    Related
    ENSP00000301046.2, ENST00000301046.6
    Conserved Domains (1) summary
    pfam00062
    Location:20138
    Lys; C-type lysozyme/alpha-lactalbumin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    48567684..48571845 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    48529699..48533867 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)