Format

Send to:

Choose Destination

LAIR2 leukocyte associated immunoglobulin like receptor 2 [ Homo sapiens (human) ]

Gene ID: 3904, updated on 1-Aug-2020

Summary

Official Symbol
LAIR2provided by HGNC
Official Full Name
leukocyte associated immunoglobulin like receptor 2provided by HGNC
Primary source
HGNC:HGNC:6478
See related
Ensembl:ENSG00000167618 MIM:602993
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD306
Summary
The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to leukocyte-associated immunoglobulin-like receptor 1, a membrane-bound receptor that modulates innate immune response. The protein encoded by this locus is a soluble receptor that may play roles in both inhibition of collagen-induced platelet aggregation and vessel formation during placental implantation. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]
Expression
Biased expression in placenta (RPKM 4.7), lymph node (RPKM 0.9) and 3 other tissues See more
Orthologs

Genomic context

See LAIR2 in Genome Data Viewer
Location:
19q13.42
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (54502810..54510693)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55014013..55021900)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene leukocyte receptor cluster member 8 Neighboring gene CDC42 effector protein 5 Neighboring gene leukocyte receptor cluster member 9 Neighboring gene uncharacterized LOC105372460 Neighboring gene killer cell immunoglobulin like receptor, three Ig domains X1 (pseudogene)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC71634

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of immune response TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
leukocyte-associated immunoglobulin-like receptor 2
Names
LAIR-2
leukocyte-associated Ig-like receptor-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002288.6NP_002279.2  leukocyte-associated immunoglobulin-like receptor 2 isoform a precursor

    See identical proteins and their annotated locations for NP_002279.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC245036, AI262718, BC069366, BX106365
    Consensus CDS
    CCDS12897.1
    UniProtKB/Swiss-Prot
    Q6ISS4
    Related
    ENSP00000301202.2, ENST00000301202.7
    Conserved Domains (1) summary
    cl11960
    Location:27120
    Ig; Immunoglobulin domain
  2. NM_021270.5NP_067154.1  leukocyte-associated immunoglobulin-like receptor 2 isoform b precursor

    See identical proteins and their annotated locations for NP_067154.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1, resulting in an isoform (b) which is shorter compared to isoform a.
    Source sequence(s)
    AC245036, AF013250, BX106365
    Consensus CDS
    CCDS12898.1
    UniProtKB/Swiss-Prot
    Q6ISS4
    Related
    ENSP00000301203.2, ENST00000351841.2
    Conserved Domains (2) summary
    smart00410
    Location:35101
    IG_like; Immunoglobulin like
    cl11960
    Location:27120
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    54502810..54510693
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526961.2XP_011525263.1  leukocyte-associated immunoglobulin-like receptor 2 isoform X1

    See identical proteins and their annotated locations for XP_011525263.1

    Conserved Domains (2) summary
    smart00410
    Location:2389
    IG_like; Immunoglobulin like
    cl11960
    Location:15108
    Ig; Immunoglobulin domain

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NW_003571054.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    409036..416888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_7

Genomic

  1. NW_003571060.1 Reference GRCh38.p13 ALT_REF_LOCI_7

    Range
    407546..415405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_9

Genomic

  1. NT_187693.1 Reference GRCh38.p13 ALT_REF_LOCI_9

    Range
    485161..493011
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center