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LAG3 lymphocyte activating 3 [ Homo sapiens (human) ]

Gene ID: 3902, updated on 17-Jun-2018
Official Symbol
LAG3provided by HGNC
Official Full Name
lymphocyte activating 3provided by HGNC
Primary source
HGNC:HGNC:6476
See related
Ensembl:ENSG00000089692 MIM:153337; Vega:OTTHUMG00000169197
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD223
Summary
Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]
Expression
Biased expression in spleen (RPKM 15.1), lymph node (RPKM 8.3) and 12 other tissues See more
Orthologs
See LAG3 in Genome Data Viewer
Location:
12p13.31
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (6772483..6778455)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6881670..6887621)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene myeloid leukemia factor 2 Neighboring gene parathymosin Neighboring gene RNA, 7SL, cytoplasmic 380, pseudogene Neighboring gene CD4 molecule

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • MHC class II antigen presentation, organism-specific biosystem (from REACTOME)
    MHC class II antigen presentation, organism-specific biosystemAntigen presenting cells (APCs) such as B cells, dendritic cells (DCs) and monocytes/macrophages express major histocompatibility complex class II molecules (MHC II) at their surface and present exog...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
MHC class II protein binding IDA
Inferred from Direct Assay
more info
PubMed 
antigen binding TAS
Traceable Author Statement
more info
PubMed 
transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
lymphocyte activation gene 3 protein
Names
lymphocyte-activation gene 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002286.5NP_002277.4  lymphocyte activation gene 3 protein precursor

    See identical proteins and their annotated locations for NP_002277.4

    Status: REVIEWED

    Source sequence(s)
    AA687676, AC125494, AI274900, X51985
    Consensus CDS
    CCDS8561.1
    UniProtKB/Swiss-Prot
    P18627
    Related
    ENSP00000203629.2, OTTHUMP00000240397, ENST00000203629.2, OTTHUMT00000402846
    Conserved Domains (3) summary
    smart00410
    Location:267348
    IG_like; Immunoglobulin like
    pfam13895
    Location:174259
    Ig_2; Immunoglobulin domain
    cl11960
    Location:263336
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    6772483..6778455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520956.1XP_011519258.1  lymphocyte activation gene 3 protein isoform X1

    Conserved Domains (3) summary
    smart00410
    Location:267348
    IG_like; Immunoglobulin like
    pfam13895
    Location:174259
    Ig_2; Immunoglobulin domain
    cl11960
    Location:263336
    Ig; Immunoglobulin domain
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