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S-Lap1 Sperm-Leucylaminopeptidase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38986, updated on 18-Sep-2024

Summary

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Official Symbol
S-Lap1provided by FlyBase
Official Full Name
Sperm-Leucylaminopeptidase 1provided by FlyBase
Primary source
FLYBASE:FBgn0035915
Locus tag
Dmel_CG6372
See related
AllianceGenome:FB:FBgn0035915
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0140519.89; bs33g03.y1; bs34e01.y1; CG6372; Dmel\CG6372; FBgn0035915; S-Lap 1; S-LAP 1
Summary
Predicted to enable peptidase activity. Involved in mushroom body development. Located in major mitochondrial derivative. Is expressed in adult head; spermatogonium; spermatozoon; and testis. Orthologous to human LAP3 (leucine aminopeptidase 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See S-Lap1 in Genome Data Viewer
Location:
66D8-66D8; 3-26 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8617235..8619474)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8610335..8612574)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Sperm-Leucylaminopeptidase 2 Neighboring gene GTPase activating protein, SECIS-dependent read-through Neighboring gene Z band alternatively spliced PDZ-motif protein 66 Neighboring gene Cell division cycle 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Recurrent gene co-amplification on Drosophila X and Y chromosomes. Ellison C, et al. PLoS Genet, 2019 Jul. PMID 31329593, Free PMC Article
  2. Expansion and functional diversification of a leucyl aminopeptidase family that encodes the major protein constituents of Drosophila sperm. Dorus S, et al. BMC Genomics, 2011 Apr 5. PMID 21466698, Free PMC Article
  3. Identification of NUB1 as a suppressor of mutant Huntington toxicity via enhanced protein clearance. Lu B, et al. Nat Neurosci, 2013 May. PMID 23525043
  4. Sperm-Leucylaminopeptidases are required for male fertility as structural components of mitochondrial paracrystalline material in Drosophila melanogaster sperm. Laurinyecz B, et al. PLoS Genet, 2019 Feb. PMID 30802236, Free PMC Article
  5. Differential microarray analysis of Drosophila mushroom body transcripts using chemical ablation. Kobayashi M, et al. Proc Natl Acad Sci U S A, 2006 Sep 26. PMID 16971484, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables metalloaminopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in major mitochondrial derivative IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Sperm-Leucylaminopeptidase 1
Names
CG6372-PA
S-Lap1-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    8617235..8619474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139987.3 → NP_648244.1  Sperm-Leucylaminopeptidase 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648244.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95U24, Q9VSM6
    Related
    FBpp0076362
    Conserved Domains (2) summary
    PRK00913
    Location:44 → 542
    PRK00913; multifunctional aminopeptidase A; Provisional
    cd00433
    Location:55 → 541
    Peptidase_M17; Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VSM6 Q9VSM6

Gene LinkOut

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