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ALKAL1 ALK and LTK ligand 1 [ Homo sapiens (human) ]

Gene ID: 389658, updated on 21-Mar-2023

Summary

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Official Symbol
ALKAL1provided by HGNC
Official Full Name
ALK and LTK ligand 1provided by HGNC
Primary source
HGNC:HGNC:33775
See related
Ensembl:ENSG00000196711 MIM:619670; AllianceGenome:HGNC:33775
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AUGA; AUGB; FAM150A; UNQ9433
Summary
Enables receptor signaling protein tyrosine kinase activator activity and receptor tyrosine kinase binding activity. Involved in positive regulation of ERK1 and ERK2 cascade; positive regulation of ERK5 cascade; and positive regulation of neuron projection development. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in gall bladder (RPKM 1.3), thyroid (RPKM 1.1) and 7 other tissues See more
Orthologs
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Genomic context

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See ALKAL1 in Genome Data Viewer
Location:
8q11.23
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (52534037..52565430, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (52910076..52941473, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (53446597..53477990, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ST18 C2H2C-type zinc finger transcription factor Neighboring gene ribosomal protein L34 pseudogene 17 Neighboring gene ST18-FAM150A intergenic CAGE-defined low expression enhancer Neighboring gene RB1 inducible coiled-coil 1 Neighboring gene uncharacterized LOC105375835

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Mechanism for the activation of the anaplastic lymphoma kinase receptor. Reshetnyak AV, et al. Nature, 2021 Dec. PMID 34819673, Free PMC Article
  2. Structural basis of cytokine-mediated activation of ALK family receptors. De Munck S, et al. Nature, 2021 Dec. PMID 34646012, Free PMC Article
  3. Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions. Reshetnyak AV, et al. Proc Natl Acad Sci U S A, 2015 Dec 29. PMID 26630010, Free PMC Article
  4. Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome. Zhang H, et al. Proc Natl Acad Sci U S A, 2014 Nov 4. PMID 25331893, Free PMC Article
  5. FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase. Guan J, et al. Elife, 2015 Sep 29. PMID 26418745, Free PMC Article

See all (10) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. activation of ALK/LTK family receptors by small ALKAL proteins (FAM150, AUG) conserved in vertebrates
    Title: ALKALs are in vivo ligands for ALK family receptor tyrosine kinases in the neural crest and derived cells.
  2. In conclusion, these data show that ALK is robustly activated by the FAM150A/B ligands.
    Title: FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase.
  3. Data show that leukocyte tyrosine kinase (LTK) ligand FAM150A (augmentor-beta; AUG-beta) is specific for LTK and only weakly binds to anaplastic lymphoma kinase (ALK).
    Title: Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions.
  4. Only two related secreted factors, FAM150A and FAM150B (family with sequence similarity 150 member A and member B), stimulated LTK phosphorylation.
    Title: Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC163513, MGC163515

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables receptor signaling protein tyrosine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables receptor signaling protein tyrosine kinase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables receptor tyrosine kinase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of ERK5 cascade IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of ERK5 cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of neuron projection development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ALK and LTK ligand 1
Names
AUG-beta
RPLK9433
augmentor beta
augmentor-alpha
family with sequence similarity 150 member A
protein FAM150A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207413.4 → NP_997296.1  ALK and LTK ligand 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC013650, AI858920, AY358213, BP423106
    Consensus CDS
    CCDS6150.1
    UniProtKB/Swiss-Prot
    B7ZMG9, Q6UXT8
    Related
    ENSP00000351345.4, ENST00000358543.9
    Conserved Domains (1) summary
    pfam15129
    Location:58 → 128
    FAM150; FAM150 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    52534037..52565430 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    52910076..52941473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6UXT8.1 GenPept UniProtKB/Swiss-Prot:Q6UXT8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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