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ALKAL1 ALK and LTK ligand 1 [ Homo sapiens (human) ]

Gene ID: 389658, updated on 11-Apr-2024

Summary

Official Symbol
ALKAL1provided by HGNC
Official Full Name
ALK and LTK ligand 1provided by HGNC
Primary source
HGNC:HGNC:33775
See related
Ensembl:ENSG00000196711 MIM:619670; AllianceGenome:HGNC:33775
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AUGA; AUGB; FAM150A; UNQ9433
Summary
Enables receptor signaling protein tyrosine kinase activator activity and receptor tyrosine kinase binding activity. Involved in positive regulation of ERK1 and ERK2 cascade; positive regulation of ERK5 cascade; and positive regulation of neuron projection development. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in gall bladder (RPKM 1.3), thyroid (RPKM 1.1) and 7 other tissues See more
Orthologs
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Genomic context

See ALKAL1 in Genome Data Viewer
Location:
8q11.23
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (52534037..52565430, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (52910076..52941473, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (53446597..53477990, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ST18 C2H2C-type zinc finger transcription factor Neighboring gene uncharacterized LOC101929341 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:53125987-53126195 Neighboring gene VISTA enhancer hs698 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27344 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_103338 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27345 Neighboring gene MPRA-validated peak7016 silencer Neighboring gene ribosomal protein L34 pseudogene 17 Neighboring gene ST18-FAM150A intergenic CAGE-defined low expression enhancer Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:53458378-53459577 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:53476246-53477222 Neighboring gene MPRA-validated peak7018 silencer Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:53512288-53512788 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:53541841-53542555 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr8:53566637-53567138 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr8:53567139-53567638 Neighboring gene RB1 inducible coiled-coil 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19188 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19189 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19190 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19191 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27347 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27348 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:53650644-53651144 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:53651145-53651645 Neighboring gene uncharacterized LOC105375835 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:53676283-53677482

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC163513, MGC163515

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ALK and LTK ligand 1
Names
AUG-beta
RPLK9433
augmentor beta
augmentor-alpha
family with sequence similarity 150 member A
protein FAM150A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207413.4NP_997296.1  ALK and LTK ligand 1 precursor

    See identical proteins and their annotated locations for NP_997296.1

    Status: VALIDATED

    Source sequence(s)
    AC013650, AI858920, AY358213, BP423106
    Consensus CDS
    CCDS6150.1
    UniProtKB/Swiss-Prot
    B7ZMG9, Q6UXT8
    Related
    ENSP00000351345.4, ENST00000358543.9
    Conserved Domains (1) summary
    pfam15129
    Location:58128
    FAM150; FAM150 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    52534037..52565430 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    52910076..52941473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)