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KTN1 kinectin 1 [ Homo sapiens (human) ]

Gene ID: 3895, updated on 6-Nov-2022

Summary

Official Symbol
KTN1provided by HGNC
Official Full Name
kinectin 1provided by HGNC
Primary source
HGNC:HGNC:6467
See related
Ensembl:ENSG00000126777 MIM:600381; AllianceGenome:HGNC:6467
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CG1; KNT; MU-RMS-40.19
Summary
This gene encodes an integral membrane protein that is a member of the kinectin protein family. The encoded protein is primarily localized to the endoplasmic reticulum membrane. This protein binds kinesin and may be involved in intracellular organelle motility. This protein also binds translation elongation factor-delta and may be involved in the assembly of the elongation factor-1 complex. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Aug 2012]
Expression
Ubiquitous expression in testis (RPKM 35.7), thyroid (RPKM 26.9) and 25 other tissues See more
Orthologs
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Genomic context

See KTN1 in Genome Data Viewer
Location:
14q22.3
Exon count:
47
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (55580207..55684584)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (49785926..49890300)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (56046925..56151302)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene abl interactor 1 pseudogene 1 Neighboring gene KTN1 antisense RNA 1 Neighboring gene uncharacterized LOC124903320 Neighboring gene ribosomal protein L13a pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0004, MGC133337

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables cadherin binding HDA PubMed 
enables kinesin binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in membrane HDA PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
kinectin
Names
CG-1 antigen
kinesin receptor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079521.2NP_001072989.1  kinectin isoform a

    See identical proteins and their annotated locations for NP_001072989.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (a).
    Source sequence(s)
    AL138499, AY536375, BQ014936, DA769269, Z22551
    Consensus CDS
    CCDS41957.1
    UniProtKB/Swiss-Prot
    Q86UP2, Q86W57
    UniProtKB/TrEMBL
    A0A024R663
    Related
    ENSP00000378725.3, ENST00000395314.8
    Conserved Domains (3) summary
    COG1196
    Location:6671352
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12128
    Location:319991
    DUF3584; Protein of unknown function (DUF3584)
    cl23763
    Location:10131202
    MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain
  2. NM_001079522.2NP_001072990.1  kinectin isoform b

    See identical proteins and their annotated locations for NP_001072990.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks two alternate in-frame exons in the coding region compared to variant 2. This variant encodes isoform b, which is shorter than isoform a.
    Source sequence(s)
    BC117132, BQ014936, DA452468, DA769269
    Consensus CDS
    CCDS41959.1
    UniProtKB/Swiss-Prot
    Q86UP2
    Related
    ENSP00000378722.1, ENST00000395311.5
    Conserved Domains (2) summary
    TIGR02168
    Location:4581246
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl23763
    Location:9901179
    MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain
  3. NM_001271014.2NP_001257943.1  kinectin isoform d

    See identical proteins and their annotated locations for NP_001257943.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region compared to variant 2. This variant encodes isoform d, which is shorter than isoform a.
    Source sequence(s)
    AK302797, BC143720, BM981127, DA769269
    UniProtKB/Swiss-Prot
    Q86UP2
    Conserved Domains (2) summary
    COG1196
    Location:3261084
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl23763
    Location:10131202
    MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain
  4. NM_001402682.1NP_001389611.1  kinectin isoform a

    Status: REVIEWED

    Source sequence(s)
    AL138499
    Consensus CDS
    CCDS41957.1
    UniProtKB/Swiss-Prot
    Q86W57
    UniProtKB/TrEMBL
    A0A024R663
  5. NM_001402683.1NP_001389612.1  kinectin isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL138499
  6. NM_001402684.1NP_001389613.1  kinectin isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL138499
  7. NM_001402685.1NP_001389614.1  kinectin isoform d

    Status: REVIEWED

    Source sequence(s)
    AL138499
  8. NM_001402686.1NP_001389615.1  kinectin isoform d

    Status: REVIEWED

    Source sequence(s)
    AL138499
  9. NM_001402687.1NP_001389616.1  kinectin isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL138499
  10. NM_001402688.1NP_001389617.1  kinectin isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL138499
  11. NM_001402689.1NP_001389618.1  kinectin isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL138499
  12. NM_001402690.1NP_001389619.1  kinectin isoform b

    Status: REVIEWED

    Source sequence(s)
    AL138499
  13. NM_001402691.1NP_001389620.1  kinectin isoform b

    Status: REVIEWED

    Source sequence(s)
    AL138499
  14. NM_001402692.1NP_001389621.1  kinectin isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL138499
  15. NM_001402693.1NP_001389622.1  kinectin isoform c

    Status: REVIEWED

    Source sequence(s)
    AL138499
  16. NM_001402694.1NP_001389623.1  kinectin isoform c

    Status: REVIEWED

    Source sequence(s)
    AL138499
    Consensus CDS
    CCDS41958.1
  17. NM_001402696.1NP_001389625.1  kinectin isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL138499
  18. NM_001402698.1NP_001389627.1  kinectin isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL138499
  19. NM_001402699.1NP_001389628.1  kinectin isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL138499
  20. NM_001402700.1NP_001389629.1  kinectin isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL138499
  21. NM_001402701.1NP_001389630.1  kinectin isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL138499
  22. NM_001402702.1NP_001389631.1  kinectin isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL138499
  23. NM_001402703.1NP_001389632.1  kinectin isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL138499
  24. NM_001402704.1NP_001389633.1  kinectin isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL138499
  25. NM_001402705.1NP_001389634.1  kinectin isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL138499
  26. NM_001402706.1NP_001389635.1  kinectin isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL138499
  27. NM_001402707.1NP_001389636.1  kinectin isoform 16

    Status: REVIEWED

    Source sequence(s)
    AL138499
  28. NM_001402708.1NP_001389637.1  kinectin isoform 17

    Status: REVIEWED

    Source sequence(s)
    AL138499
  29. NM_001402709.1NP_001389638.1  kinectin isoform 18

    Status: REVIEWED

    Source sequence(s)
    AL138499
  30. NM_001402710.1NP_001389639.1  kinectin isoform 19

    Status: REVIEWED

    Source sequence(s)
    AL138499
  31. NM_001402711.1NP_001389640.1  kinectin isoform 20

    Status: REVIEWED

    Source sequence(s)
    AL138499
  32. NM_004986.4NP_004977.2  kinectin isoform c

    See identical proteins and their annotated locations for NP_004977.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons in the coding region compared to variant 2. This variant encodes isoform c, which is shorter than isoform a.
    Source sequence(s)
    BM981127, DA769269, L25616
    Consensus CDS
    CCDS41958.1
    UniProtKB/Swiss-Prot
    Q86UP2
    Related
    ENSP00000391964.2, ENST00000438792.6
    Conserved Domains (1) summary
    COG1196
    Location:3261050
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RNA

  1. NR_073128.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses two and lacks two alternate internal exons compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AY264265, BC050555, BC112337, BM981127, DA769269
  2. NR_073129.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses two alternate internal exons compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AY264265, DA769269
    Related
    ENST00000459737.5
  3. NR_175283.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL138499
  4. NR_175284.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL138499
  5. NR_175285.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL138499
  6. NR_175286.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL138499
  7. NR_175287.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL138499
  8. NR_175288.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL138499
  9. NR_175289.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL138499
  10. NR_175290.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL138499

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    55580207..55684584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006720138.3XP_006720201.1  kinectin isoform X1

    UniProtKB/Swiss-Prot
    Q86UP2
    UniProtKB/TrEMBL
    A0A024R663
    Conserved Domains (3) summary
    COG1196
    Location:6671352
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12128
    Location:319991
    DUF3584; Protein of unknown function (DUF3584)
    cl23763
    Location:10131202
    MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain
  2. XM_047431360.1XP_047287316.1  kinectin isoform X3

  3. XM_017021282.3XP_016876771.1  kinectin isoform X4

    UniProtKB/Swiss-Prot
    Q86UP2
    Conserved Domains (1) summary
    COG1196
    Location:3261050
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  4. XM_047431361.1XP_047287317.1  kinectin isoform X5

  5. XM_047431362.1XP_047287318.1  kinectin isoform X6

  6. XM_006720139.4XP_006720202.1  kinectin isoform X2

    UniProtKB/Swiss-Prot
    Q86UP2
    Conserved Domains (2) summary
    COG1196
    Location:3261084
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl23763
    Location:10131202
    MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain
  7. XM_006720140.5XP_006720203.1  kinectin isoform X3

    Conserved Domains (1) summary
    COG1196
    Location:4461227
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  8. XM_006720141.4XP_006720204.1  kinectin isoform X5

    Conserved Domains (1) summary
    TIGR02168
    Location:4801251
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  9. XM_024449579.2XP_024305347.1  kinectin isoform X6

    Conserved Domains (1) summary
    cl25732
    Location:4481213
    SMC_N; RecF/RecN/SMC N terminal domain
  10. XM_047431363.1XP_047287319.1  kinectin isoform X7

RNA

  1. XR_943438.3 RNA Sequence

  2. XR_943439.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    49785926..49890300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_182926.2: Suppressed sequence

    Description
    NM_182926.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.