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KTN1 kinectin 1 [ Homo sapiens (human) ]

Gene ID: 3895, updated on 4-Oct-2020

Summary

Official Symbol
KTN1provided by HGNC
Official Full Name
kinectin 1provided by HGNC
Primary source
HGNC:HGNC:6467
See related
Ensembl:ENSG00000126777 MIM:600381
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CG1; KNT; MU-RMS-40.19
Summary
This gene encodes an integral membrane protein that is a member of the kinectin protein family. The encoded protein is primarily localized to the endoplasmic reticulum membrane. This protein binds kinesin and may be involved in intracellular organelle motility. This protein also binds translation elongation factor-delta and may be involved in the assembly of the elongation factor-1 complex. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Aug 2012]
Expression
Ubiquitous expression in testis (RPKM 35.7), thyroid (RPKM 26.9) and 25 other tissues See more
Orthologs

Genomic context

See KTN1 in Genome Data Viewer
Location:
14q22.3
Exon count:
49
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (55580207..55684584)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (56046925..56151302)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene abl interactor 1 pseudogene 1 Neighboring gene KTN1 antisense RNA 1 Neighboring gene ribosomal protein L13a pseudogene 3 Neighboring gene long intergenic non-protein coding RNA 520

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0004, MGC133337

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
cadherin binding HDA PubMed 
kinesin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
microtubule-based movement IEA
Inferred from Electronic Annotation
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane HDA PubMed 

General protein information

Preferred Names
kinectin
Names
CG-1 antigen
kinesin receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079521.2NP_001072989.1  kinectin isoform a

    See identical proteins and their annotated locations for NP_001072989.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (a).
    Source sequence(s)
    AL138499, AY536375, BQ014936, DA769269, Z22551
    Consensus CDS
    CCDS41957.1
    UniProtKB/Swiss-Prot
    Q86UP2
    UniProtKB/TrEMBL
    A0A024R663
    Related
    ENSP00000378725.3, ENST00000395314.8
    Conserved Domains (3) summary
    COG1196
    Location:6671352
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12128
    Location:319991
    DUF3584; Protein of unknown function (DUF3584)
    cl23763
    Location:10131202
    MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain
  2. NM_001079522.2NP_001072990.1  kinectin isoform b

    See identical proteins and their annotated locations for NP_001072990.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks two alternate in-frame exons in the coding region compared to variant 2. This variant encodes isoform b, which is shorter than isoform a.
    Source sequence(s)
    BC117132, BQ014936, DA452468, DA769269
    Consensus CDS
    CCDS41959.1
    UniProtKB/Swiss-Prot
    Q86UP2
    Related
    ENSP00000378722.1, ENST00000395311.5
    Conserved Domains (2) summary
    TIGR02168
    Location:4581246
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl23763
    Location:9901179
    MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain
  3. NM_001271014.2NP_001257943.1  kinectin isoform d

    See identical proteins and their annotated locations for NP_001257943.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region compared to variant 2. This variant encodes isoform d, which is shorter than isoform a.
    Source sequence(s)
    AK302797, BC143720, BM981127, DA769269
    UniProtKB/Swiss-Prot
    Q86UP2
    Conserved Domains (2) summary
    COG1196
    Location:3261084
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl23763
    Location:10131202
    MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain
  4. NM_004986.4NP_004977.2  kinectin isoform c

    See identical proteins and their annotated locations for NP_004977.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons in the coding region compared to variant 2. This variant encodes isoform c, which is shorter than isoform a.
    Source sequence(s)
    BM981127, DA769269, L25616
    Consensus CDS
    CCDS41958.1
    UniProtKB/Swiss-Prot
    Q86UP2
    Related
    ENSP00000391964.2, ENST00000438792.6
    Conserved Domains (1) summary
    COG1196
    Location:3261050
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RNA

  1. NR_073128.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses two and lacks two alternate internal exons compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AY264265, BC050555, BC112337, BM981127, DA769269
  2. NR_073129.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses two alternate internal exons compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AY264265, DA769269
    Related
    ENST00000459737.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    55580207..55684584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006720141.3XP_006720204.1  kinectin isoform X8

    Conserved Domains (1) summary
    TIGR02168
    Location:4801251
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  2. XM_024449579.1XP_024305347.1  kinectin isoform X10

    Conserved Domains (1) summary
    cl25732
    Location:4481213
    SMC_N; RecF/RecN/SMC N terminal domain
  3. XM_011536752.2XP_011535054.1  kinectin isoform X2

    Conserved Domains (2) summary
    TIGR02168
    Location:4581247
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl23763
    Location:9901179
    MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain
  4. XM_017021286.2XP_016876775.1  kinectin isoform X11

  5. XM_017021279.2XP_016876768.1  kinectin isoform X6

  6. XM_006720138.2XP_006720201.1  kinectin isoform X1

    See identical proteins and their annotated locations for XP_006720201.1

    UniProtKB/Swiss-Prot
    Q86UP2
    UniProtKB/TrEMBL
    A0A024R663
    Conserved Domains (3) summary
    COG1196
    Location:6671352
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12128
    Location:319991
    DUF3584; Protein of unknown function (DUF3584)
    cl23763
    Location:10131202
    MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain
  7. XM_017021280.1XP_016876769.1  kinectin isoform X6

  8. XM_011536753.2XP_011535055.1  kinectin isoform X5

    See identical proteins and their annotated locations for XP_011535055.1

    UniProtKB/Swiss-Prot
    Q86UP2
    Related
    ENSP00000394992.2, ENST00000413890.6
    Conserved Domains (2) summary
    TIGR02168
    Location:4581246
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl23763
    Location:9901179
    MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain
  9. XM_006720139.3XP_006720202.1  kinectin isoform X3

    See identical proteins and their annotated locations for XP_006720202.1

    UniProtKB/Swiss-Prot
    Q86UP2
    Conserved Domains (2) summary
    COG1196
    Location:3261084
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl23763
    Location:10131202
    MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain
  10. XM_017021284.2XP_016876773.1  kinectin isoform X9

  11. XM_006720140.4XP_006720203.1  kinectin isoform X4

    See identical proteins and their annotated locations for XP_006720203.1

    Conserved Domains (1) summary
    COG1196
    Location:4461227
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  12. XM_017021285.2XP_016876774.1  kinectin isoform X9

  13. XM_017021282.2XP_016876771.1  kinectin isoform X7

    UniProtKB/Swiss-Prot
    Q86UP2
    Conserved Domains (1) summary
    COG1196
    Location:3261050
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  14. XM_011536751.3XP_011535053.1  kinectin isoform X1

    See identical proteins and their annotated locations for XP_011535053.1

    UniProtKB/Swiss-Prot
    Q86UP2
    UniProtKB/TrEMBL
    A0A024R663
    Conserved Domains (3) summary
    COG1196
    Location:6671352
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12128
    Location:319991
    DUF3584; Protein of unknown function (DUF3584)
    cl23763
    Location:10131202
    MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain
  15. XM_017021283.1XP_016876772.1  kinectin isoform X7

    UniProtKB/Swiss-Prot
    Q86UP2
    Conserved Domains (1) summary
    COG1196
    Location:3261050
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  16. XM_017021278.1XP_016876767.1  kinectin isoform X1

    UniProtKB/Swiss-Prot
    Q86UP2
    UniProtKB/TrEMBL
    A0A024R663
    Conserved Domains (3) summary
    COG1196
    Location:6671352
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12128
    Location:319991
    DUF3584; Protein of unknown function (DUF3584)
    cl23763
    Location:10131202
    MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain
  17. XM_017021281.1XP_016876770.1  kinectin isoform X6

RNA

  1. XR_001750312.2 RNA Sequence

  2. XR_943438.2 RNA Sequence

  3. XR_943439.2 RNA Sequence

  4. XR_001750311.2 RNA Sequence

  5. XR_001750310.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_182926.2: Suppressed sequence

    Description
    NM_182926.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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