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OR6B2 olfactory receptor family 6 subfamily B member 2 [ Homo sapiens (human) ]

Gene ID: 389090, updated on 1-Aug-2020

Summary

Official Symbol
OR6B2provided by HGNC
Official Full Name
olfactory receptor family 6 subfamily B member 2provided by HGNC
Primary source
HGNC:HGNC:15041
See related
Ensembl:ENSG00000182083
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR2-1; OR6B2P
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Orthologs

Genomic context

See OR6B2 in Genome Data Viewer
Location:
2q37.3
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (240029491..240030429, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (240968382..240972324, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC150935 Neighboring gene NADH:ubiquinone oxidoreductase subunit A10 Neighboring gene microRNA 4786 Neighboring gene olfactory receptor family 6 subfamily B member 3 Neighboring gene olfactory receptor family 9 subfamily S member 24 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Identification of regions associated with variation in sensitivity to food-related odors in the human genome.
NHGRI GWA Catalog

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
odorant binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
detection of chemical stimulus involved in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
olfactory receptor 6B2
Names
olfactory receptor OR2-1
olfactory receptor, family 6, subfamily B, member 2 pseudogene

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005853.1NP_001005853.1  olfactory receptor 6B2

    See identical proteins and their annotated locations for NP_001005853.1

    Status: PROVISIONAL

    Source sequence(s)
    AB065663
    Consensus CDS
    CCDS46559.1
    UniProtKB/Swiss-Prot
    Q6IFH4
    Related
    ENSP00000384563.2, ENST00000402971.3
    Conserved Domains (1) summary
    cd15224
    Location:40294
    7tmA_OR6B-like; olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    240029491..240030429 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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