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PLEKHM3 pleckstrin homology domain containing M3 [ Homo sapiens (human) ]

Gene ID: 389072, updated on 1-Jun-2020

Summary

Official Symbol
PLEKHM3provided by HGNC
Official Full Name
pleckstrin homology domain containing M3provided by HGNC
Primary source
HGNC:HGNC:34006
See related
Ensembl:ENSG00000178385
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAPR; PLEKHM1L
Expression
Ubiquitous expression in brain (RPKM 3.2), thyroid (RPKM 2.8) and 25 other tissues See more
Orthologs

Genomic context

See PLEKHM3 in Genome Data Viewer
Location:
2q33.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (207821288..208025675, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (208686012..208890284, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14B pseudogene 2 Neighboring gene cyclin Y like 1 Neighboring gene microRNA 4775 Neighboring gene frizzled class receptor 5 Neighboring gene HNF1 motif-containing MPRA enhancer 152 Neighboring gene RNA, U6 small nuclear 360, pseudogene Neighboring gene ribosomal protein L9 pseudogene 14 Neighboring gene RNA, 5S ribosomal pseudogene 116

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41210, AC083900.1, DKFZp686O04200

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
myoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
pleckstrin homology domain-containing family M member 3
Names
PH domain-containing family M member 3
differentiation associated protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080475.3NP_001073944.1  pleckstrin homology domain-containing family M member 3

    See identical proteins and their annotated locations for NP_001073944.1

    Status: VALIDATED

    Source sequence(s)
    AC083900, AC093698, AC096772
    Consensus CDS
    CCDS42808.1
    UniProtKB/Swiss-Prot
    Q6ZWE6
    Related
    ENSP00000417003.2, ENST00000427836.8
    Conserved Domains (4) summary
    cd13327
    Location:364451
    PH_PLEKHM3_2; Pleckstrin homology domain-containing family M member 3 Pleckstrin homology domain 2
    cd14674
    Location:214303
    PH_PLEKHM3_1; Pleckstrin homology domain-containing family M member 3 Pleckstrin homology domain 1
    pfam00169
    Location:362454
    PH; PH domain
    pfam13901
    Location:529729
    zf-RING_9; Putative zinc-RING and/or ribbon

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    207821288..208025675 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004073.1XP_016859562.1  pleckstrin homology domain-containing family M member 3 isoform X7

  2. XM_005246545.3XP_005246602.1  pleckstrin homology domain-containing family M member 3 isoform X5

    Conserved Domains (4) summary
    cd13327
    Location:364451
    PH_PLEKHM3_2; Pleckstrin homology domain-containing family M member 3 Pleckstrin homology domain 2
    cd14674
    Location:214303
    PH_PLEKHM3_1; Pleckstrin homology domain-containing family M member 3 Pleckstrin homology domain 1
    pfam00169
    Location:362454
    PH; PH domain
    pfam13901
    Location:529651
    zf-RING_9; Putative zinc-RING and/or ribbon
  3. XM_017004072.2XP_016859561.1  pleckstrin homology domain-containing family M member 3 isoform X6

    Related
    ENSP00000395354.1, ENST00000447645.5
  4. XM_011511160.2XP_011509462.1  pleckstrin homology domain-containing family M member 3 isoform X1

    See identical proteins and their annotated locations for XP_011509462.1

    UniProtKB/Swiss-Prot
    Q6ZWE6
    Conserved Domains (4) summary
    cd13327
    Location:364451
    PH_PLEKHM3_2; Pleckstrin homology domain-containing family M member 3 Pleckstrin homology domain 2
    cd14674
    Location:214303
    PH_PLEKHM3_1; Pleckstrin homology domain-containing family M member 3 Pleckstrin homology domain 1
    pfam00169
    Location:362454
    PH; PH domain
    pfam13901
    Location:529729
    zf-RING_9; Putative zinc-RING and/or ribbon
  5. XM_006712521.4XP_006712584.1  pleckstrin homology domain-containing family M member 3 isoform X4

    Conserved Domains (4) summary
    cd13327
    Location:364451
    PH_PLEKHM3_2; Pleckstrin homology domain-containing family M member 3 Pleckstrin homology domain 2
    cd14674
    Location:214303
    PH_PLEKHM3_1; Pleckstrin homology domain-containing family M member 3 Pleckstrin homology domain 1
    pfam00169
    Location:362454
    PH; PH domain
    pfam13901
    Location:529650
    zf-RING_9; Putative zinc-RING and/or ribbon
  6. XM_017004071.1XP_016859560.1  pleckstrin homology domain-containing family M member 3 isoform X2

  7. XM_011511163.2XP_011509465.1  pleckstrin homology domain-containing family M member 3 isoform X3

    Related
    ENSP00000400150.1, ENST00000457206.1
    Conserved Domains (4) summary
    cd13327
    Location:364451
    PH_PLEKHM3_2; Pleckstrin homology domain-containing family M member 3 Pleckstrin homology domain 2
    cd14674
    Location:214303
    PH_PLEKHM3_1; Pleckstrin homology domain-containing family M member 3 Pleckstrin homology domain 1
    pfam00169
    Location:362454
    PH; PH domain
    pfam13901
    Location:529652
    zf-RING_9; Putative zinc-RING and/or ribbon
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