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CCDC188 coiled-coil domain containing 188 [ Homo sapiens (human) ]

Gene ID: 388849, updated on 26-Oct-2022

Summary

Official Symbol
CCDC188provided by HGNC
Official Full Name
coiled-coil domain containing 188provided by HGNC
Primary source
HGNC:HGNC:51899
See related
Ensembl:ENSG00000234409 AllianceGenome:HGNC:51899
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 5.7), spleen (RPKM 0.8) and 10 other tissues See more
Orthologs
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Genomic context

See CCDC188 in Genome Data Viewer
Location:
22q11.21
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (20148416..20151055, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (20527451..20530096, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (20135939..20138578, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene RAN binding protein 1 Neighboring gene small nucleolar RNA, H/ACA box 77B Neighboring gene zinc finger DHHC-type palmitoyltransferase 8 Neighboring gene Sharpr-MPRA regulatory region 11686 Neighboring gene enhancer-blocking element 22-3 upstream of CCDC188

Genomic regions, transcripts, and products

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
coiled-coil domain-containing protein 188

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365892.2NP_001352821.1  coiled-coil domain-containing protein 188

    Status: VALIDATED

    Source sequence(s)
    AC006547
    Consensus CDS
    CCDS93123.1
    UniProtKB/Swiss-Prot
    H7C350
    Related
    ENSP00000409542.2, ENST00000439765.4
    Conserved Domains (2) summary
    pfam14992
    Location:359401
    TMCO5; TMCO5 family
    cl21462
    Location:158184
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    20148416..20151055 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005261241.4XP_005261298.1  coiled-coil domain-containing protein 188 isoform X7

    Conserved Domains (1) summary
    pfam11068
    Location:192267
    YlqD; YlqD protein
  2. XM_047441359.1XP_047297315.1  coiled-coil domain-containing protein 188 isoform X3

  3. XM_011530171.3XP_011528473.1  coiled-coil domain-containing protein 188 isoform X6

    Conserved Domains (2) summary
    pfam14335
    Location:208286
    DUF4391; Domain of unknown function (DUF4391)
    cl21462
    Location:158184
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
  4. XM_005261239.4XP_005261296.1  coiled-coil domain-containing protein 188 isoform X5

    Conserved Domains (1) summary
    cl21462
    Location:158184
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
  5. XM_005261238.4XP_005261295.1  coiled-coil domain-containing protein 188 isoform X4

    Conserved Domains (1) summary
    cl21462
    Location:158184
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
  6. XM_047441357.1XP_047297313.1  coiled-coil domain-containing protein 188 isoform X1

  7. XM_047441358.1XP_047297314.1  coiled-coil domain-containing protein 188 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    20527451..20530096 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001243537.1: Suppressed sequence

    Description
    NM_001243537.1: This RefSeq was removed because the CDS was partial.