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KRTDAP keratinocyte differentiation associated protein [ Homo sapiens (human) ]

Gene ID: 388533, updated on 21-Dec-2019

Summary

Official Symbol
KRTDAPprovided by HGNC
Official Full Name
keratinocyte differentiation associated proteinprovided by HGNC
Primary source
HGNC:HGNC:16313
See related
Ensembl:ENSG00000188508 MIM:617212
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KDAP; UNQ467
Summary
This gene encodes a protein which may function in the regulation of keratinocyte differentiation and maintenance of stratified epithelia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Restricted expression toward skin (RPKM 815.2) See more
Orthologs

Genomic context

See KRTDAP in Genome Data Viewer
Location:
19q13.12
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (35487324..35490464, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35978226..35981433, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1531 Neighboring gene uncharacterized LOC101927522 Neighboring gene free fatty acid receptor 2 Neighboring gene dermokine Neighboring gene suprabasin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Clone Names

  • MGC163373

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
epidermis development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
lamellar body IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
keratinocyte differentiation-associated protein
Names
KIPV467

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030050.1 RefSeqGene

    Range
    5068..8208
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001244847.2NP_001231776.1  keratinocyte differentiation-associated protein isoform 2 precursor

    See identical proteins and their annotated locations for NP_001231776.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AI184682, AY359007, BC130501, W95920
    Consensus CDS
    CCDS59377.1
    UniProtKB/Swiss-Prot
    P60985
    Related
    ENSP00000470713.1, ENST00000484218.6
    Conserved Domains (1) summary
    pfam15200
    Location:2485
    KRTDAP; Keratinocyte differentiation-associated
  2. NM_207392.3NP_997275.1  keratinocyte differentiation-associated protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_997275.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI184682, AY359007, BC130501
    Consensus CDS
    CCDS12462.1
    UniProtKB/Swiss-Prot
    P60985
    Related
    ENSP00000339251.3, ENST00000338897.4
    Conserved Domains (1) summary
    pfam15200
    Location:2499
    KRTDAP; Keratinocyte differentiation-associated

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    35487324..35490464 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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