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TMEM220 transmembrane protein 220 [ Homo sapiens (human) ]

Gene ID: 388335, updated on 22-Sep-2022

Summary

Official Symbol
TMEM220provided by HGNC
Official Full Name
transmembrane protein 220provided by HGNC
Primary source
HGNC:HGNC:33757
See related
Ensembl:ENSG00000187824 AllianceGenome:HGNC:33757
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver (RPKM 14.0), small intestine (RPKM 7.1) and 23 other tissues See more
Orthologs
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Genomic context

See TMEM220 in Genome Data Viewer
Location:
17p13.1
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (10711133..10730023, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (10618686..10637574, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (10614450..10633340, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903927 Neighboring gene myosin heavy chain 3 Neighboring gene synthesis of cytochrome C oxidase 1 Neighboring gene Sharpr-MPRA regulatory region 5903 Neighboring gene ADP-ribose/CDP-alcohol diphosphatase, manganese dependent Neighboring gene mago homolog 2, pseudogene Neighboring gene TMEM220 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 1671 Neighboring gene transmembrane protein 238 like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

EBI GWAS Catalog

Description
Common variants in left/right asymmetry genes and pathways are associated with relative hand skill.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004313.3NP_001004313.1  transmembrane protein 220 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001004313.1

    Status: VALIDATED

    Source sequence(s)
    AC002347
    Consensus CDS
    CCDS32567.1
    UniProtKB/Swiss-Prot
    B9EGW3, Q6QAJ8
    Related
    ENSP00000339830.4, ENST00000341871.8
    Conserved Domains (1) summary
    pfam15071
    Location:23111
    TMEM220; Transmembrane family 220, helix
  2. NM_001330139.3NP_001317068.1  transmembrane protein 220 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC002347
    Consensus CDS
    CCDS82075.1
    UniProtKB/Swiss-Prot
    Q6QAJ8
    Related
    ENSP00000396973.2, ENST00000455996.6
    Conserved Domains (1) summary
    pfam15071
    Location:25101
    TMEM220; Transmembrane family 220, helix
  3. NM_001330140.3NP_001317069.1  transmembrane protein 220 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC002347
    Consensus CDS
    CCDS82074.1
    UniProtKB/Swiss-Prot
    Q6QAJ8
    UniProtKB/TrEMBL
    J3KSZ3
    Related
    ENSP00000462723.1, ENST00000578345.1
  4. NM_001359647.2NP_001346576.1  transmembrane protein 220 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC002347
    Conserved Domains (1) summary
    pfam15071
    Location:25101
    TMEM220; Transmembrane family 220, helix

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    10711133..10730023 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024616.2XP_016880105.1  transmembrane protein 220 isoform X1

  2. XM_011523835.3XP_011522137.1  transmembrane protein 220 isoform X3

    Conserved Domains (1) summary
    pfam15071
    Location:2396
    TMEM220; Transmembrane family 220, helix
  3. XM_047435960.1XP_047291916.1  transmembrane protein 220 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    10618686..10637574 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)