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SPDYE4 speedy/RINGO cell cycle regulator family member E4 [ Homo sapiens (human) ]

Gene ID: 388333, updated on 12-Oct-2019

Summary

Official Symbol
SPDYE4provided by HGNC
Official Full Name
speedy/RINGO cell cycle regulator family member E4provided by HGNC
Primary source
HGNC:HGNC:35463
See related
Ensembl:ENSG00000183318 MIM:617628
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Restricted expression toward testis (RPKM 1.5) See more
Orthologs

Genomic context

See SPDYE4 in Genome Data Viewer
Location:
17p13.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (8747532..8759428, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8650849..8661977, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371525 Neighboring gene uncharacterized LOC105371526 Neighboring gene coiled-coil domain containing 42 Neighboring gene uncharacterized LOC105371529 Neighboring gene uncharacterized LOC105371530 Neighboring gene major facilitator superfamily domain containing 6 like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from BioSystems

  • Oocyte meiosis, organism-specific biosystem (from KEGG)
    Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
  • Oocyte meiosis, conserved biosystem (from KEGG)
    Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
  • Progesterone-mediated oocyte maturation, organism-specific biosystem (from KEGG)
    Progesterone-mediated oocyte maturation, organism-specific biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
  • Progesterone-mediated oocyte maturation, conserved biosystem (from KEGG)
    Progesterone-mediated oocyte maturation, conserved biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
speedy protein E4
Names
putative Speedy protein E4
speedy homolog E4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128076.3NP_001121548.1  speedy protein E4

    See identical proteins and their annotated locations for NP_001121548.1

    Status: VALIDATED

    Source sequence(s)
    AW303450, BC146949
    Consensus CDS
    CCDS45609.1
    UniProtKB/Swiss-Prot
    A6NLX3
    Related
    ENSP00000329522.6, ENST00000328794.10
    Conserved Domains (1) summary
    pfam11357
    Location:104233
    Spy1; Cell cycle regulatory protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    8747532..8759428 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256633.4XP_005256690.1  speedy protein E4 isoform X1

    See identical proteins and their annotated locations for XP_005256690.1

    UniProtKB/Swiss-Prot
    A6NLX3
    Conserved Domains (1) summary
    pfam11357
    Location:104233
    Spy1; Cell cycle regulatory protein
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