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CLEC12B C-type lectin domain family 12 member B [ Homo sapiens (human) ]

Gene ID: 387837, updated on 26-Nov-2021

Summary

Official Symbol
CLEC12Bprovided by HGNC
Official Full Name
C-type lectin domain family 12 member Bprovided by HGNC
Primary source
HGNC:HGNC:31966
See related
Ensembl:ENSG00000256660 MIM:617573
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UNQ5782
Expression
Biased expression in testis (RPKM 8.0), skin (RPKM 1.6) and 1 other tissue See more
Orthologs
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Genomic context

See CLEC12B in Genome Data Viewer
Location:
12p13.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (10006138..10018800)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (10163226..10171399)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene CLEC12A antisense RNA 1 Neighboring gene C-type lectin domain family 12 member A Neighboring gene C-type lectin domain family 1 member B Neighboring gene uncharacterized LOC102724020 Neighboring gene C-type lectin domain family 1 member B pseudogene Neighboring gene C-type lectin domain containing 9A Neighboring gene C-type lectin domain family 1 member A Neighboring gene RN7SK pseudogene 161

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of sensory disturbances in the inferior alveolar nerve after bilateral sagittal split ramus osteotomy.
GeneReviews: Not available
Genome-wide meta-analysis of systolic blood pressure in children with sickle cell disease.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables protein phosphatase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein phosphatase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor inhibitor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in external side of plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
C-type lectin domain family 12 member B
Names
macrophage antigen h
testis secretory sperm-binding protein Li 205a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001129998.3NP_001123470.1  C-type lectin domain family 12 member B isoform 1

    See identical proteins and their annotated locations for NP_001123470.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC024224
    Consensus CDS
    CCDS44830.1
    UniProtKB/Swiss-Prot
    Q2HXU8
    UniProtKB/TrEMBL
    A0A140VK10
    Related
    ENSP00000344563.5, ENST00000338896.11
    Conserved Domains (1) summary
    cd03593
    Location:143265
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
  2. NM_001319241.1NP_001306170.1  C-type lectin domain family 12 member B isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the central region and initiates translation at a downstream start codon compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AI655492, AK131027, BG484230, BM563861
    Conserved Domains (1) summary
    cd03593
    Location:40162
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
  3. NM_001319242.1NP_001306171.1  C-type lectin domain family 12 member B isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the central region, initiates translation at a downstream start codon, and differs in the 3' coding region and 3' UTR compared to variant 1. The resulting protein (isoform 4) has a shorter N-terminus and a shorter, distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC024224, BC036036, BG484230
    Conserved Domains (1) summary
    cd03593
    Location:40124
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
  4. NM_001387138.1NP_001374067.1  C-type lectin domain family 12 member B isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC024224
    Conserved Domains (1) summary
    cd03593
    Location:143236
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
  5. NM_205852.3NP_995324.2  C-type lectin domain family 12 member B isoform 2

    See identical proteins and their annotated locations for NP_995324.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR compared to variant 1. The resulting protein (isoform 2) has a shorter, distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK128243, AY358810, BC036036, BG484230, DQ368812
    Consensus CDS
    CCDS8610.1
    UniProtKB/Swiss-Prot
    Q2HXU8
    Related
    ENSP00000379759.1, ENST00000396502.5
    Conserved Domains (1) summary
    cd03593
    Location:143227
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RNA

  1. NR_135049.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 3' region compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI655492, AY358810, BG484230, DQ368812

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    10006138..10018800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520663.2XP_011518965.1  C-type lectin domain family 12 member B isoform X4

  2. XM_024448977.1XP_024304745.1  C-type lectin domain family 12 member B isoform X3

  3. XM_017019295.1XP_016874784.1  C-type lectin domain family 12 member B isoform X5

    Conserved Domains (1) summary
    cd03593
    Location:40162
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
  4. XM_011520658.2XP_011518960.1  C-type lectin domain family 12 member B isoform X1

    Conserved Domains (1) summary
    cd03593
    Location:134256
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
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