Format

Send to:

Choose Destination

IFITM5 interferon induced transmembrane protein 5 [ Homo sapiens (human) ]

Gene ID: 387733, updated on 3-Feb-2021

Summary

Official Symbol
IFITM5provided by HGNC
Official Full Name
interferon induced transmembrane protein 5provided by HGNC
Primary source
HGNC:HGNC:16644
See related
Ensembl:ENSG00000206013 MIM:614757
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OI5; BRIL; DSPA1; Hrmp1; fragilis4
Summary
This gene encodes a membrane protein thought to play a role in bone mineralization. This gene is located on chromosome 11 in a cluster of related genes which are induced by interferon, however, this gene has not been shown to be interferon inducible. A similar gene, located in a gene cluster on mouse chromosome 7, is a member of the interferon-inducible fragilis gene family. The mouse gene encodes a transmembrane protein described as participating in germ cell competence. A mutation in the 5' UTR of this gene has been associated with osteogenesis imperfecta type V (PMID: 22863190, 22863195). [provided by RefSeq, Aug 2012]
Expression
Low expression observed in reference dataset See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See IFITM5 in Genome Data Viewer
Location:
11p15.5
Exon count:
2
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (298200..299526, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (298200..299526, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene NLR family pyrin domain containing 6 Neighboring gene protein-glucosylgalactosylhydroxylysine glucosidase Neighboring gene mitochondrial ribosomal protein S24 pseudogene 1 Neighboring gene interferon induced transmembrane protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC190475, MGC190629

Gene Ontology Provided by GOA

Process Evidence Code Pubs
bone mineralization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
bone morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bone morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
regulation of bone mineralization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
interferon-induced transmembrane protein 5
Names
bone-restricted ifitm-like protein
bone-restricted interferon-induced transmembrane protein-like protein
dispanin subfamily A member 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032892.1 RefSeqGene

    Range
    5001..6327
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001025295.3NP_001020466.1  interferon-induced transmembrane protein 5

    See identical proteins and their annotated locations for NP_001020466.1

    Status: REVIEWED

    Source sequence(s)
    AA460254, BC150562, BQ574249, CR747200
    Consensus CDS
    CCDS31323.1
    UniProtKB/Swiss-Prot
    A6NNB3
    Related
    ENSP00000372059.2, ENST00000382614.2
    Conserved Domains (1) summary
    pfam04505
    Location:3192
    CD225; Interferon-induced transmembrane protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    298200..299526 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center